Searchable abstracts of presentations at key conferences in endocrinology

ea0090p116 | Endocrine-related Cancer | ECE2023

Impact of Gender on Treatment Decisions and Outcome in Patients with Neuroendocrine Neoplasms

Beck Julia , Siebenhuner Alexander , Wild Damian , Christ Emanuel , Refardt Julie

Introduction/Background: Gender differences affect the treatment of several diseases in both male and female patients. However, the influence of gender on treatment decisions and outcome in neuroendocrine neoplasms (NENs) has scarcely been investigated. Aims: Comparison of tumor characteristics, treatment decisions and outcome of patients with NENs, stratified by genderMaterial and Methods: Retrospective analysis of the SwissNET co...

ea0049ep918 | Neuroendocrinology | ECE2017

Copeptin after arginine infusion for the differential diagnosis of the polyuria–polydipsia syndrome “The CARGO-Study”

Winzeler Bettina , Nigro Nicole , Refardt Julie , Christ-Crain Mirjam

Background: The spectrum of polyuria-polydipsia syndrome (PPS) includes diabetes insipidus (central or nephrogenic) and primary polydipsia. In clinical practice the differential diagnosis particularly of central diabetes insipidus (cDI) and primary polydipsia (PP) is often difficult. The current gold standard – the water deprivation test (WDT) with or without vasopressin (AVP) measurements – lacks reliable diagnostic accuracy. Arginine infusion is known to stimulate ...

ea0073aep89 | Calcium and Bone | ECE2021

Normalization of SIAD-induced hyponatremia stimulates osteoblast function

Potasso Laura , Refardt Julie , Meier Christian , Christ-Crain Mirjam

BackgroundHyponatremia is associated with increased risk of bone fragility and fractures. In vitro studies suggest a role of hyponatremia in stimulating osteoclast activation, whereas other studies rather revealed a possible role of acute hyponatremia in impairing osteoblast function. We aimed to assess whether and how correction of hyponatremia in hospitalized patients with the syndrome of inappropriate antidiuresis (SIAD) has an impact on bone...

ea0081p154 | Pituitary and Neuroendocrinology | ECE2022

Role of apparent strong ion difference in the differential diagnosis of thiazide associated hyponatremia

Potasso Laura , Refardt Julie , Monnerat Sophie , Winzeler Bettina , Christ-Crain Mirjam

Background: Differential diagnosis of hyponatremia is challenging, particularly for thiazide associated hyponatremia (TAH), as patients might have either volume depletion in need for fluid substitution or syndrome of inappropriate antidiuresis (SIAD)-like presentation requiring fluid restriction. Urine indices are of little utility, because they are influenced by thiazide therapy. Apparent strong ion difference (aSID) describes the relation between sodium, potassium and chlori...

ea0090p32 | Calcium and Bone | ECE2023

Plasma Sodium Increase Is Associated With an Increase in Bone Formation in Outpatients With Chronic SIAD - A Predefined Secondary Analysis of the SANDx Trial

Monnerat Sophie , Refardt Julie , Potasso Laura , Meier Christian , Christ-Crain Mirjam

Introduction: Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with increased mortality and morbidity, including an increased risk for osteoporosis and fragility fractures. Preclinical studies suggest osteoclast upregulation whereas a clinical study showed improved osteoblast fuction after hyponatremia normalization in hospitalized patients with SIAD.Methods: This is a secondary analysis of a double-...

ea0090p119 | Endocrine-related Cancer | ECE2023

Improvement of Lung NET Management through standardized Care – a Swiss nationwide observational Study

Schmidlin Moira , Sadowski Samira , Siebenhuner Alexander , Wild Damian , Christ Emanuel , Refardt Julie

Introduction/ Background: Typical (TC) and atypical carcinoids (AC) are the most common neuroendocrine tumors (NETs) of the lung. Being a rare disease, the management of these tumors varies widely among Swiss centers. The impact of guidelines introduced in 2015 is unknown.Aims: Comparison of the management of Swiss patients before and after the publication of the expert consensus of the European Neuroendocrine Tumor Society (ENETS) in 2015.<p class="...

ea0063gp242 | Anterior and Posterior Pituitary | ECE2019

Copeptin levels in SIADH – a marker of malignant disease?

Winzeler Bettina , Steinmetz Michelle , Refardt Julie , Cesana-Nigro Nicole , Popovic Milica , Fenske Wiebke , Christ-Crain Mirjam

Context: Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a very common condition in hospitalized patients. It is crucial to establish the cause of SIADH especially in order to exclude or detect an underlying malignancy. As SIADH can be caused by paraneoplastically produced arginine vasopressin (AVP), we hypothesized that its stable surrogate marker copeptin may be used as a diagnostic tool.Methods: We analyzed ...

ea0049ep889 | Neuroendocrinology | ECE2017

Empagliflozin increases urinary volume output in healthy volunteers with artificial SIADH – a placebo-controlled double blind crossover study

Refardt Julie , Winzeler Bettina , Meienberg Fabian , Vogt Deborah , Christ-Crain Mirjam

Introduction: The Syndrome of inappropriate antidiuresis (SIADH) is the predominant cause of hyponatremia and its therapy options are unsatisfying. SGLT2-inhibitors have become a valuable treatment option for type 2 diabetes by increasing glucose excretion in the urine with concomitant osmotic diuresis. We therefore hypothesized that SGLT2-inhibitors could be a novel treatment option for SIADH.Material and methods: We included 14 healthy volunteers in th...

ea0070aep593 | Pituitary and Neuroendocrinology | ECE2020

Course of serum potassium levels during the hypertonic saline infusion test for diagnosis of diabetes insipidus

Potasso Laura , Refardt Julie , Chifu Irina , Fassnacht Martin , Kristin Fenske Wiebke , Christ-Crain Mirjam

Introduction: Onset of hyperkalemia has previously been reported during the administration of hypertonic resuscitation solutions. Since the hypertonic saline infusion test has recently been validated for the diagnosis of diabetes insipidus, we aimed to investigate the course of plasma potassium levels during the test.Material and Methods: Data of 144 patients undergoing osmotic stimulation with hypertonic saline infusion at 11 tertiary medical centres in...

ea0099p321 | Pituitary and Neuroendocrinology | ECE2024

Apelin and copeptin levels in patients with chronic SIAD treated with empagliflozin – a secondary analysis of the SANDx trial

Monnerat Sophie , Drivakos Nikolaos , A. Chapman Fiona , Dhaun Neeraj , Refardt Julie , Christ-Crain Mirjam

Introduction: Glucose-induced osmotic diuresis and free water loss induced by the SGLT2 inhibitor empagliflozin effectively increase sodium levels in patients with a chronic syndrome of inappropriate antidiuresis (SIAD) where arginine vasopressin (AVP) levels are inappropriately increased in relation to osmolality. The hormone apelin opposes the actions of AVP in salt and water homeostasis and administering exogenous apelin increases sodium levels in rats with SIAD. In patient...