Searchable abstracts of presentations at key conferences in endocrinology

ea0011oc50 | Calcium and bone OC49 Novartis Oncology Young Investigator Award | ECE2006

Congenitally hypothyroid mice with (Pax8−/−) or without (hyt/hyt) functional TSH receptors (TSHR) display equivalent skeletal phenotypes

Williams GR , Swinhoe R , Murphy E , Williams AJ , Costagliola S , Vassart G , Howell PGT , Boyde A , Flamant F , Samarut J , Weiss R , Refetoff S , Bassett JHD

Studies of TSHR−/− mice suggest that TSH inhibits bone turnover, but these mice have congenital hypothyroidism and the actions of TSH cannot be separated from effects of thyroid hormone deficiency. We characterised skeletal development in hyt/hyt mice, which have a point mutation in the Tshr gene, and Pax8−/− mice with thyroid gland agenesis. Hyt/hyt mice have a 100-fold increase in TSH but inactive TSHRs, whereas Pax8&...

ea0011p820 | Thyroid | ECE2006

Application of positron emission tomography (PET) in the study of cerebral glucose uptake in hypothyroid rats: effect of T3 administration

De Servi M , Belcari N , Bernal J , Refetoff S , Salvadori P , Gianetti E , De Marco G , Tonacchera M , Vitti P , Del Guerra A , Pinchera A

Thyroid hormone (TH) plays a major role in nervous system development. Its deficiency causes severe brain malfunction, which in the human results in cretinism. With the recent availability of new imaging techniques, as small animal PET, it is now possible to study cerebral metabolism in vivo. The aim of this work was to study the in vivo effect of TH on the brain of hypothyroid rats in terms of metabolic function, using PET scanning. For the experiment we used th...