ea0022p57 | Adrenal | ECE2010
Dexneit Thomas
, Sbiera Silviu
, Schmull Sebastian
, van den Brandt Jens
, Kraus Luitgart
, Beyer Melanie
, Mlynski Robert
, Reichardt Holger
, Allolio Bruno
, Fassnacht Martin
Introduction: Glucocorticoids (GC) are used for immunosuppression in many clinical conditions. Pre-clinical and early clinical studies suggested that the induction of regulatory T (Treg) cells contributes to the immunosupressive effects of GCs. However, in the hitherto reported clinical studies only patients with ongoing autoimmune diseases were included. Our goal, therefore, was to determine the influence of exogenous GCs in vivo in immunocompetent subjects and mice.</...