Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep36 | Adrenal and Cardiovascular Endocrinology | ECE2021

The acute effects of milk intake on calcium homeostasis and cardiovascular outcome: A randomized, crossover trial in postmenopausal women

Espersen Rasmus , Rejnmark Lars

IntroductionThe importance of calcium intake from dairy has been investigated in several studies with discrepant results. Meta-analyses have shown beneficial effects of dairy intake on cardiovascular health with an inverse association between intake and cardiovascular disease. However, a recent trial has suggested an increase in blood pressure in the hours following intake of 1000 mg of calcium citrate compared with placebo. So far, it has not been inves...

ea0090p33 | Calcium and Bone | ECE2023

Heart rate and blood pressure, but not pulse wave velocity, are higher among adults with hereditary hypophosphatemia compared to healthy controls: a cross-sectional study

Espersen Rasmus , Beck-Nielsen Signe , Rejnmark Lars

Introduction: Hereditary hypophosphatemia (HH) are rare diseases, characterized by increased levels of fibroblast growth factor 23 (FGF23), excessive renal phosphate wasting and inappropriately low 1,25-dihydroxy-vitamin D causing hypophosphatemia. In children, the diseases manifest as rickets and osteomalacia, in adults only osteomalacia. Studies in cardiovascular risk among patients with HH are few and inconclusive. Some have found left ventricular hypertrophy in children an...

ea0070aep153 | Bone and Calcium | ECE2020

Risk of fractures in primary hyperparathyroidism: A systematic review and metaanalysis

Svensson Henriette , Rolighed Lars , Harsløf Torben , Rejnmark Lars

Background and objectiveAn increased risk of fractures in Primary Hyperparathyroidism (PHPT) has been reported in a number of relatively small studies. Performing a systematic literature search we identified available studies and calculated common estimates by pooling results from the individual studies in a meta-analysis.Methods: Searching EMBASE and PubMed using both free text word search and Mesh terms we identified published st...

ea0070aep212 | Bone and Calcium | ECE2020

Renal complications in patients with chronic hypoparathyroidism receiving conventional therapy: A systematic literature review

Gosmanova Elvira , Houillier Pascal , Bilezikian John , Marelli Claudio , Rejnmark Lars

Conventional therapy for chronic hypoparathyroidism is oral calcium and active vitamin D; despite treatment, chronic hypoparathyroidism may be associated with increased risk of renal complications. Without the effect of parathyroid hormone on renal tubular reabsorption, calcium-conserving and phosphaturic effects are lost, serum calcium levels are reduced and serum phosphate levels are increased. This may lead to hypercalciuria and hyperphosphataemia, which may be associated w...

ea0081rc8.3 | Rapid Communications 8: Calcium and Bone | ECE2022

What is the most efficient way to fortify food items with vitamin D? A randomised, multiple crossover study

Espersen Rasmus , Ring Madsen Lene , Nebel Caroline , Danielsen Marianne , Dalsgaard Trine , Rejnmark Lars

Introduction: Vitamin D insufficiency (25-hydroxy vitamin D <50 nmol/l) is a global health problem. Vitamin D food fortification might be the solution, but knowledge is sparse on whether fortification of various food items affects the bioavailability differently. It is generally assumed that ingesting vitamin D with a fatty meal improves the bioavailability of vitamin D. Furthermore, complex formation with whey protein isolate (WPI) may enhance the stability of vitamin D a...

ea0084op-01-02 | Oral Session 1: Topic Highlights | ETA2022

A randomized, double-blind, placebo-controlled trial of Vitamin D supplementation in patients newly diagnosed with graves’ disease

Grove-Laugesen Diana , Ebbehoj Eva , Hansen Klavs , Watt Torquil , Rejnmark Lars

Objective: Vitamin D has potential immunomodulatory effects. We studied whether vitamin D3 supplementation affects the course of Graves’ disease (GD).Methods: In a double-blind, placebo-controlled design, we randomized patients with a first time diagnosis of GD hyperthyroidism to daily supplementation with vitamin D3 70 mg (2800 IU) or placebo, as add-on to standard treatment with anti-thyroid drugs (ATD). The intervention was continued 12 months af...

ea0063p514 | Calcium and Bone 2 | ECE2019

Vitamin D insufficiency and hyperparathyroidism, general health and quality of life – a cross sectional study

Bislev Lise Sofie , Rodbro Lene Langagergaard , Rolighed Lars , Sikjaer Tanja , Rejnmark Lars

Introduction: Multiple adverse health outcomes are reported in response to low vitamin D and/or hyperparathyroidism.Aim and methods: A cross-sectional study in a random sample of mainly non-vitamin D supplemented Danish women (N=1580) during winter-time. We investigated prevalence of vitamin D insufficiency, hyperparathyroidism, general health and quality of life (QoL) as assessed by a general health questionnaire and a validated hyperparathyroi...

ea0070oc2.5 | Bone and Calcium | ECE2020

Effect of nine months of vitamin D supplementation on areal and volumetric bone mass density and bone architecture in graves’ disease: a double-blinded, randomized clinical trial

Grove-Laugesen Diana , Ebbehoj Eva , Watt Torquil , Würgler Hansen Klavs , Rejnmark Lars

Background: Vitamin D is important to skeletal health and is standard care in conditions with low BMD. Thyrotoxicosis caused by Graves’ disease (GD) leads to increased bone turnover and reduced BMD. We aimed to test the hypothesis that vitamin D supplementation would improve bone recovery in GD.Methods: Using a double-blinded design, hyperthyroid patients with a first time diagnosis of GD were randomized to supplementation with vitamin D3 70 mg/day...

ea0073pep6.6 | Presented ePosters 6: Calcium and Bone | ECE2021

Cardiovascular events in adult patients with chronic hypoparathyroidism treated with rhPTH(1–84) compared with a historical control cohort

Kaul Sanjiv , Ayodele Olulade , Sherry Nicole , Swallow Elyse , Mu Fan , Berman Richard , Gosmanova Elvira , Rejnmark Lars

This study investigated risk of cardiovascular (CV) events over a period of up to 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), compared with a historical control cohort of patients who did not receive rhPTH(1––84). The rhPTH(1–84)-treated patient cohort was derived from the NCT00732615 (REPLACE), NCT01...

ea0073pep6.7 | Presented ePosters 6: Calcium and Bone | ECE2021

Change in estimated glomerular filtration rate in adult patients with chronic hypoparathyroidism treated with rhPTH(1–84) compared with a historical control cohort

Ayodele Olulade , Rejnmark Lars , Sherry Nicole , Swallow Elyse , Briggs Allison , Lax Angela , Gosmanova Elvira

Changes in estimated glomerular filtration rate (eGFR) over 5 years were evaluated in adult patients with chronic hypoparathyroidism. A cohort of patients treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), was derived from NCT01297309 (RACE) and NCT01199614 (HEXT) clinical trials. A historical control patient cohort with hypoparathyroidism who did not receive rhPTH(1–84) or rhPTH(1&#...