Searchable abstracts of presentations at key conferences in endocrinology

ea0011p845 | Thyroid | ECE2006

The glutathione peroxidase 3 promoter is activated by Pax8

Mentrup B , Renault N , Schmutzler C , Köhrle J

The selenoenzyme plasma glutathione peroxidase (GPx3, pGPx) is highly expressed in thyroid, kidney, placenta and bronchio-epithelial tissue. In the thyroid gland, the enzyme is thought to regulate thyroid hormone production by controlling the availability of H2O2, the cosubstrate for thyroperoxidase (TPO) and to protect the thyrocyte against H2O2-induced oxidative damage. To explain the high thyroidal expression levels, we studied GP...