Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc7.2 | Adrenal Clinical | ICEECE2012

Activation of the PKA pathway triggers formation of an illicit serotonergic regulatory loop in primary pigmented nodular adrenal disease (PPNAD) tissues associated with Cushing’s syndrome

Bram Z. , Renouf S. , Duparc C. , Ragazzon B. , Libe R. , Martinez A. , Stratakis C. , Bertherat J. , Louiset E. , Lefebvre H.

In the normal adrenal gland, serotonin (5-HT) stimulates cortisol secretion through activation of 5-HT4 receptors whereas, in some macronodular adrenal hyperplasia tissues, the corticotropic effect of 5-HT is mediated by ectopic 5-HT7 receptors. The aim of the present study was to investigate the role of 5-HT in the control of cortisol secretion in PPNAD tissues from 12 patients by using molecular, immunohistochemical and pharmacological approaches. RT-PCR studies revealed ove...

ea0029oc13.3 | Adrenal Basic | ICEECE2012

Cortisol secretion is dependent on intraadrenal production of ACTH in macronodular bilateral adrenal hyperplasia causing Cushings syndrome

Louiset E. , Duparc C. , Young J. , Boutelet I. , Renouf S. , Bram Z. , Groussin L. , Caron P. , Tabarin A. , Grunenberger F. , Christin-Maitre S. , Kuhn J. , Anouar Y. , Bertherat J. , Lefebvre H.

Illicit expression of membrane receptors for circulating regulatory factors, such as gastric inhibitory polypeptide (GIP), luteinizing hormone (LH) and serotonin (5-HT) receptors, has been well documented in ACTH-independent macronodular adrenal hyperplasias (AIMAHs) causing CushingÂ’s syndrome. In addition, we have observed an abnormal expression of ACTH in some steroidogenic cells in two AIMAH tissues. The aim of the present study was to investigate the role of local pro...