Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.23.08 | Thyroid – diagnosis | ECE2015

Clinical characteristics in sporadic and familial medullary thyroid carcinomas: worse outcome in sporadic cases even when disease stage at diagnosis is similar

Saltiki Katerina , Spanou Loukia , Kouki Sofia , Rentziou Gianna , Vasileiou Vasiliki , Anastasiou Eleni , Alevizaki Maria

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

ea0035p1102 | Thyroid Cancer | ECE2014

Familial medullary thyroid carcinomas: RET mutation in exon 8 is associated with better prognosis but increased risk for other malignancies

Saltiki Katerina , Rentziou Gianna , Angelopoulou Anastasia , Apostolakis Michael , Papathoma Alexandra , Alevizaki Maria

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...

ea0032p1085 | Thyroid cancer | ECE2013

Pre-existing autoimmune thyroid disease may influence the course of the disease in differentiated thyroid carcinoma patients

Athanasiadou Anastasia , Saltiki Katerina , Rentziou Gianna , Papageorgiou George , Anastasiou Eleni , Alevizaki Maria

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

ea0032p1121 | Thyroid cancer | ECE2013

Clinical and biochemical criteria for the prognosis of small medullary thyroid carcinomas

Saltiki Katerina , Rentziou Gianna , Vasileiou Vasiliki , Athanasiadou Anastasia , Anastasiou Eleni , Alevizaki Maria

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...

ea0022p841 | Thyroid | ECE2010

Effects of rhTSH administration on 24 h arterial pressure in subjects undergoing evaluation for differentiated thyroid cancer

Rentziou Gianna , Manios Eustathios , Mantzou Emily , Saltiki Katerina , Michas Fotios , Zakopoulos Nikos , Alevizaki Maria

Background: TSH levels within the normal range have been associated with increased blood pressure (BP). TSH itself might be involved, especially as extrathyroidal actions of TSH exist.We investigated whether elevated TSH levels after acute rhTSH administration may result in alterations in BP in euthyroid individuals.Methods: Twenty-six euthyroid female subjects thyroidectomised and on T4 suppressive dose, were evaluated ...