Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep976 | Thyroid (non-cancer) | ECE2015

Efficacy of two different L-thyroxine formulations in dyspeptic patients with subclinical hypothyroidism

Ribichini Danilo , Vaira Berardino , Pasquali Renato

Levo-thyroxine (LT4) formulations are available on tablets (TAB) or liquid solution (SOL). LT4 TAB absorption could be affected by several gastric diseases as Helicobacter pylori (HP) infection or chronic atrophic gastritis (CAG), instead no data are available on absorption of the LT4 SOL in these conditions. The aim of the study was to compare the efficacy of TAB or SOL LT4 formulations in patients with dyspeptic syndrome (DS) and subclinical ...

ea0063p521 | Calcium and Bone 2 | ECE2019

A rare case of cushing disease and hypophosphatasia

Preiato Valentina Lo , Zavatta Guido , Ribichini Danilo , Altieri Paola , Pelusi Carla , Pagotto Uberto

Cushing disease and hypophosphatasia are rare conditions that may be both responsible of an important impairment of bone metabolism with increased fracture risk. We reported for the first time a case of a 43-year-old woman that came at our attention for recent onset of alopecia and amenorrhea. At the anamnesis, she denied any past relevant events and no drug assumption. At the physical examination, she presented rubeosis and facies lunaris and central adipose distribution (wai...

ea0063p1040 | Interdisciplinary Endocrinology 2 | ECE2019

Diabetes and Nivolumab: 2 clinical cases compared

Preiato Valentina Lo , Salvagni Stefania , Ribichini Danilo , Ardizzoni Andrea , Pagotto Uberto , Pelusi Carla

Monoclonal antibodies against the Programmed cell death-1 protein (PD-1) are a new treatment for advanced cancer. Endocrine and metabolic diseases are known to be frequently associated with this class of drugs. We describe two cases of Nivolumab-induced diabetes mellitus.Case 1: A 73-year-old man with a mutated BRAF-V600K advanced stage melanoma was treated with Nivolumab (240 mg IV every 2 weeks). He had normal-weight (BMI: 21.6 Kg/mq), and no previous ...

ea0037ep1220 | Clinical Cases–Pituitary/Adrenal | ECE2015

Occurrence of liver failure in post-surgery hypopituitaric patients

Lo Preiato Valentina , Ribichini Danilo , Baccini Margherita , Pasquali Renato , Pagotto Uberto

Multiple pituitary hormone deficit and hypothalamic obesity are common complications after brain surgery for childhood tumors. Despite adequate replacement hormone therapy, obesity develops equally, but liver failure is not usually described. In this study, four subjects who had undergone surgery for brain tumors involving the peri-hypothalamic area when they were nursing or as youths (9 months, 6 years, 9 years and 20 years). They were referred to our Unit when they were 19, ...

ea0014p528 | (1) | ECE2007

Adulthood follow-up of a large number of patients with congenital morphological alteration of anterior and/or posterior pituitary lobes

Ribichini Danilo , Ragazzini Cecilia , Zucchini Stefano , Pirazzoli Piero , Cicognani Alessandro , Vicennati Valentina , Pagotto Uberto , Pasquali Renato

Congenital morphological alteration of anterior and/or posterior pituitary lobes is a rare disease often associated with isolated or multiple hormonal deficiency. In this study we re-evaluated 24 adult patients, 20 males and 4 females, (23–46 years), in whom Nuclear Magnetic Resonance (NMR) showed congenital morphological alteration of the gland. Twenty out of 24 patients presented with an association of hypoplasic adenohypophysis and ectopic neurohypophysis, while 4 pres...

ea0081p323 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Sleep quality in patients with type 1 diabetes: a large cross-sectional study

Bongiorno Claudio , Moscatiello Simona , Laffi Gilberto , Ribichini Danilo , Lo Preiato Valentina , Grimaldi Michele , Pagotto Uberto , Di Dalmazi Guido

Background: Altered sleep quality and duration have been reported in 26-67% of patients with type 1 diabetes (T1D). However, differences in study designs, populations, and methods of sleep quality assessment have led to heterogeneous results in terms of association with clinical data and blood glucose parameters.Aims: To investigate the sleep quality of a large cohort of adult patients with autoimmune diabetes under insulin treatment, and to analyze the ...

ea0056p645 | Endocrine Disruptors | ECE2018

Endocrine related adverse events associated with immune checkpoint blockade therapy: a retrospective analysis

Preiato Valentina Lo , Salvagni Stefania , Gianni Caterina , Ribichini Danilo , Bianchi Nicola , Pagotto Uberto , Ardizzoni Andrea , Pelusi Carla

Background: Immune checkpoint inhibitors (ICI) have become a clinically validated treatment for numerous types of tumor including melanoma, lung, and kidney carcinoma. These treatments can cause immune-related adverse events affecting several organs including the endocrine system.Aims: The aim of this study was to characterize the type and the onset of the ICI associated-endocrinopathies.Materials and methods: This retrospective co...

ea0016p550 | Obesity | ECE2008

Endocrine and metabolic alterations in narcoleptic patients as result of orexin-A reduction

Dalmazi Guido , Poli Francesca , Ribichini Danilo , Fanelli Flaminia , Vicennati Valentina , de Iasio Rosaria , Montagna Pasquale , Pasquali Renato , Plazzi Giuseppe , Pagotto Uberto

Aims: Narcolepsy with cataplexy (NC) is a rare, chronic disease, characterized by excessive daytime sleepiness, cataplexy, disrupted nocturnal sleep and manifestations of abnormal REM (Rapid Eye Movement) sleep. Human NC is probably caused by environmental and genetic factors, leading to dysfunctions in hypothalamic orexigenic neurons. Recent studies showed that NC was associated with an increase in Body Mass Index, despite a reduction in food intake. In the current study we i...