Searchable abstracts of presentations at key conferences in endocrinology

ea0015p146 | Diabetes, metabolism and cardiovascular | SFEBES2008

Comparison of the effects of cannabinoid receptor modulation on adipogenesis in human primary preadipocytes and a murine cell line

Agarwal Neera , Rice Samuel , Zhang Lei , Rees Aled , Ludgate Marian

Background: CB1 antagonism has potential benefits in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and peripheral action on adipose tissue. We have previously demonstrated the inhibitory effects of CB1 inactivation on preadipocyte proliferation and now extend these studies to in vitro adipogenesis.Aims: To compare the effects of CB1 agonism and antagonism on differentiation in both preadipocyte cell lines and ...

ea0025p222 | Pituitary | SFEBES2011

Has you appearance changed over the last few years? Oh I’m really ugly now!

Eligar Vinay Somashekar , Dacruz Thomas , Thind Munveer , Rao Srinivas , Williams Meurig , Rice Samuel

Forty two year Mrs SJ, community support worker with a background history of hypothyroidism was referred by her GP with excessive tiredness and weight gain. She had been attending her surgery for few months with somatic symptoms and her GP had noticed significant change in facial characteristics and large hands. She complained of increase in her feet size from a size 6 to a 9. No disturbance of vision was reported.She was noted to have hyperglycaemia and...