Searchable abstracts of presentations at key conferences in endocrinology

ea0020htb4 | Hot topics: Basic | ECE2009

Mice deficient for the Sam68 RNA binding protein are protected from dietary obesity and insulin resistance

Vogel Gillian , Richard Stephane

The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism. The tyrosine phosphorylation of Sam68 was shown to negatively regulate its RNA binding activity and hence it was termed a Signal Transduction Activator of RNA (STAR) protein. Although KH-type RNA binding domains are known to mediate specific protein-RNA interactions, their RNA targets remain elusive. Nevertheless, Sam68 h...