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ea0063gp166 | Obesity (1) | ECE2019

Results from the phase 3 multicenter SONICS study of levoketoconazole: subgroup analysis of Cushing’s syndrome patients with diabetes mellitus

Fleseriu Maria , Pivonello Rosario , Elenkova Atanaska , Salvatori Roberto , Auchus Richard J. , Feelders Richard A. , Geer Eliza B. , Greenman Yona , Witek Przemyslaw , Cohen Frederic , Biller Beverly MK

Background: Cushings syndrome (CS) has numerous comorbidities, including diabetes mellitus (DM). Levoketoconazole is a ketoconazole stereoisomer in clinical trials for treatment of CS.Methods: SONICS is a prospective, open-label, phase 3 maintenance-of-benefit study in adults with confirmed CS and mean urinary free cortisol (mUFC) of ≥1.5x upper limit of normal (ULN). Repeated hospitalization due to hyperglycemia or any complication related t...

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Endocrine Abstracts

Results from the phase 3 multicenter SONICS study of levoketoconazole: subgroup analysis of Cushing’s syndrome patients with diabetes mellitus

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