Searchable abstracts of presentations at key conferences in endocrinology

ea0077cc5 | (1) | SFEBES2021

Transformation of a non-functional to a functional neuroendocrine tumour

Gohil Shailesh , Reddy Narendra , Levy Miles , Kamil Anver , Richards Cathy , Bhake Ragini

Case: A 69 year old man was diagnosed with poorly differentiated pancreatic adenocarcinoma with liver metastases in November 2017 and received FOLFIRINOX chemotherapy followed by Gemcitabine. This stabilised his disease and chemotherapy was stopped in March 2020. In April 2021 he presented with a 3-4 month history of tiredness; intermittent confusion, especially in the early morning; the discovery that food resolved his symptoms, albeit temporarily; and accompanying significan...

ea0080OC2 | Oral Communications | UKINETS2021

Tracking circulating cell free tumour derived DNA in patients with neuroendocrine neoplasms

Gohil Shailesh , Page Karen , Hastings Rob , Iwuji Chinenye , Richards Cathy , Shaw Jacqui , Levy Miles

Introduction: There is a clinical need to develop novel and better biomarkers to monitor patients with neuroendocrine neoplasms (NENs). Our aim was to identify and track plasma circulating cell free tumour derived DNA (ctDNA) in a cohort of patients using a personalised, patient specific approach.Materials and methods: 35 serial plasma samples were collected from 9 patients with metastatic NENs (6 small intestinal and 1 each of lung, ovarian, and pelvic;...