Searchable abstracts of presentations at key conferences in endocrinology

ea0011p478 | Endocrine tumours and neoplasia | ECE2006

Functioning adrenocortical carcinoma and the clinical endocrinologist: toxic treatments and poor prognosis

Thomas RM , Bliss R , Richardson D , Johnson S , Turner S , Bennett S , Quinton R

Adrenocortical carcinoma (ACC) is a rare and highly malignant tumour with a poor prognosis with an incidence of 1 – 2 per million population per year. We report 2 cases of functioning ACC.Case 1: An 80 yr old with a history of hypertension, paroxysmal atrial fibrillation and cerebrovascular disease presented with leg ulcers, peripheral oedema, tiredness, weight gain, plethora and proximal myopathy. ACTH-independent Cushing’s syndrome was confir...

ea0019p56 | Clinical practice/governance and case reports | SFEBES2009

Pituitary ACTH-dependent Cushing’s syndrome caused by ectopic CRF secretion from an intra-adrenal phaeochromocytoma

Woods D , Arutchealvam V , Madathil A , Peaston R , Turner S , Neely RDG , Graham J , Richardson D , Lennard TJW , Bliss R , Bennett SB , Johnson S , Mason JI , Quinton R

A 69-year-old woman was admitted with new uncontrolled diabetes, severe hypertension and bilateral leg oedema. Cushing’s syndrome was suspected when she developed resistant hypokalemic alkalosis on diuretic therapy. Detailed questioning also revealed a history of episodic sweating, palpitation and tremor.Investigation & management: ACTH-dependant Cushing’s syndrome was confirmed: Serum ACTH 516 ng/l; urine free cortisol 20 045 nmol/24 h; 09...

ea0011p526 | Endocrine tumours and neoplasia | ECE2006

Estrone and cortisol co-secreting adrenocortical carcinoma in a man presenting with hypogonadotrophic hypogonadism and painful gynaecomastia

Lim EL , Razvi S , Vaikkakara S , Ibrahim IM , Turner S , Johnson S , Mason JI , Lennard TJW , Bliss R , Elloitt S , Richardson D , Neely RD , Quinton R

Case report: A 56-year old man presented with a 3 month history of painful bilateral gynaecomastia and sexual dysfunction. Investigations revealed hypogonadotrophic hypogonadism with markedly elevated serum E2, but otherwise normal baseline anterior pituitary function. Tumour markers were negative and adrenal androgens and LFTs were normal. Imaging identified a ∼6 cm right adrenal mass. Preoperative workup excluded phaechromocytoma, but identified low-grade, ACTH-indepen...