Searchable abstracts of presentations at key conferences in endocrinology

ea0014p203 | (1) | ECE2007

Decreased 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys

Wiegand Susanna , Richardt Anna , Remer Thomas , Wudy Stefan A , Tomlinson Jeremy W , Grüters Annette , Stewart Paul M , Strasburger Christian J , Quinkler Marcus

Objective: The incidence of childhood obesity and type 2 diabetes has reached epidemic proportions. Glucocorticoid excess causes central obesity and diabetes mellitus as seen in CushingÂ’s syndrome. The 11beta-hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1), which is predominantly expressed in liver and adipose tissue, regenerates active cortisol from inactive cortisone. Increased 11beta-HSD1 may cause tissue-specific Cushing syndrome with central obesity and impa...

ea0013p193 | Diabetes, metabolism and cardiovascular | SFEBES2007

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese children

Wiegand Susanna , Richardt Anna , Remer Thomas , Wudy Stefan A , Tomlinson Jeremy W , Hughes Beverly , Grüters Annette , Stewart Paul M , Strasburger Christian J , Quinkler Marcus

Objective: The incidence of childhood obesity and type 2 diabetes has reached epidemic proportions. Glucocorticoid excess causes central obesity and diabetes mellitus as seen in CushingÂ’s syndrome. The 11beta-hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1), which is predominantly expressed in liver and adipose tissue, regenerates active cortisol from inactive cortisone. Altered 11beta-HSD1 may cause tissue-specific Cushing syndrome with central obesity and impair...