Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps1-02-18 | Hypothyroidism | ETA2022

Human cerebral organoids as in vitro platform to assess thyroid hormone system disrupting chemicals

Fernandez-Vallone Valeria , Hellwig Lina , Opitz Robert , Obermayer-Wasserscheid Benedikt , Wiese Niklas , Rijntjes Eddy , Kohrle Josef , Mergenthaler Philipp , Stachelscheid Harald

Thyroid hormones (TH) play a fundamental role in brain development. Changes on TH availability during pregnancy and early childhood can lead to neurological disorders. Accordingly, concerns are mounting that exposure to environmental compounds capable of interfering with TH action can disrupt neuronal development. Current approaches to categorize chemicals as thyroid hormone system disrupting chemicals (THSDC) are mainly based on determination of changes in circulating TH conc...

ea0090rc1.3 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2023

Sex specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II

Demircan Kamil , Hybsier Sandra , Chillon Thilo Samson , Vetter Valentin Max , Rijntjes Eddy , Steinhagen-Thiessen Elisabeth , Demuth Ilja , Schomburg Lutz

Objective: The aim of this study was to investigate sex-specific associations of two established serum selenium biomarkers, i.e. total selenium and selenoprotein P with type 2 diabetes mellitus (T2D) and hypertension in a large cohort of older people.Methods: 1500 participants with available selenium measurements from the Berlin Aging Study II (BASE-II) were included in this study. In the serum samples, spectroscopy was used to quantify total selenium, a...

ea0084ps2-09-81 | Thyroid Hormone ACTION | ETA2022

An experimental framework for probing molecular mechanisms of local thyroid hormone action during cortical neurogenesis in human cerebral organoids

Amber Julie Bresser Audrey , Graffunder Adina , Anthofer Larissa , Megges Matthias , Obermayer-Wasserscheid Benedikt , Rijntjes Eddy , Wiese Niklas , Fernandez-Vallone Valeria , Stachelscheid Harald , Kuhnen Peter , Opitz Robert

Recently, human cerebral organoids (hCOs) emerged as powerful three-dimensional in vitro models recapitulating key aspects of early human cerebral cortex development. Improved protocols for hCO generation from induced pluripotent stem cells (hiPSC) paved the way for new disease modeling approaches and enable multimodal analyses of perturbed neurogenesis resulting from manipulation of signaling pathways or gene function. These prospects prompted us to adopt this techno...