Searchable abstracts of presentations at key conferences in endocrinology

ea0038p141 | Growth and development | SFEBES2015

Inter-correlations between placental genes regulating foetal glucocorticoid exposure and IGF2 in maternal severe obesity: a mechanism for higher birthweight?

Mina Theresia , Riley Simon , Norman Jane , Reynolds Rebecca

Background: Maternal obesity in pregnancy associates with higher birthweight. A key pathway is through placental regulation of hormones controlling foetal growth. As excess foetal glucocorticoid exposure associates with lower birthweight and since placental Insulin-like Growth Factor (IGF2) may be modulated by glucocorticoids, we hypothesised that the expression profiles of placental genes leading to reduced glucocorticoid exposure and increased IGF2 mRNA level correlate with ...

ea0037oc7.3 | Neuroendocrinology and pituitary-basic | ECE2015

Maternal distress associates with placental genes regulating foetal glucocorticoid exposure and IGF2: role of obesity and sex

Mina Theresia , Raikkonen Katri , Riley Simon , Norman Jane , Reynolds Rebecca

Introduction: Maternal distress, including poorer life satisfaction, increased anxiety and depression (A&D) symptoms, are worse in Severely Obese (SO) than lean pregnancy and may alter placental genes regulating foetal glucocorticoid exposure and placental growth. We hypothesised that the associations between increased maternal distress with changes in placental mRNA levels leading to a reduced placental barrier to maternal glucocorticoids, and altered placental IGF2, are ...

ea0031p143 | Growth and development | SFEBES2013

Reduced glucocorticoid action in obese pregnancy associates with increased birth weight and macrosomia

O'Reilly James , Riley Simon , Critchley Hilary , Seckl Jonathan , Reynolds Rebecca

Background: One in five women is obese at antenatal booking. Maternal obesity increases risk of offspring complications including higher birthweight. We hypothesised that this is mediated by altered action of maternal glucocorticoids, key regulators of fetal growth and development. We compared cortisol levels during pregnancy and placental glucocorticoid sensitivity in obese and lean women.Methods: With ethical approval serum cortisol levels were measure...

ea0034p336 | Reproduction | SFEBES2014

Elevation of HRPE773 (ZG16B) expression in amnion at term and in human ectocervical cell lines treated with inflammatory mediators is consistent with a function in innate immunity

Hayhurst Rachel Rachel , Hibbert Nanette , Frew Lorraine , Stock Sarah , Riley Simon , Morley Steven

Introduction: Labour is an inflammatory process involving the innate immune system, premature activation of which, for example by infection, can lead to preterm birth before 37 weeks of gestation with profound pathophysiological consequences for the offspring. The putative antimicrobial protein HRPE773 (ZG16B) expressed in human female reproductive secretory epithelia, has been shown previously to be elevated in human endometrium during the menstrual early secretory phase and ...

ea0028p191 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Maternal Obesity in Human Pregnancy is Associated with Altered Placental Expression of Key Genes in Fetal Growth During the First Trimester, but not at Term

O'Reilly James , Drake Amanda , Jones Rebecca , Critchley Hilary , Riley Simon , Seckl Jonathan , Reynolds Rebecca

Background: Maternal obesity during pregnancy is associated with adverse effects on fetal growth and development. As the placenta is a key organ regulating fetal growth, we hypothesized that maternal obesity is associated with altered placental expression and DNA methylation of genes regulating fetal growth and glucocorticoid metabolism and aimed to investigate this in first trimester (F; <12 weeks gestation) and term (T;>37 weeks gestation) placental tissues.<p cl...