Searchable abstracts of presentations at key conferences in endocrinology

ea0084op-07-33 | Oral Session 7: Thyroid Cancer Basic | ETA2022

HüRthle cell tumors vs oncocytic variants of the follicular cell derived thyroid tumours: a comprehensive analysis based in transcriptome, proteome and cnv profiling

Canberk Sule , ferreira marta , Oliveira Carla , reis joana , barros rita , pereira luisa , osorio hugo , Rios Elisabete , Soares Paula , Maximo Valdemar

Objectives: Hürthle cell (oncocytic) lesions can be metaplastic or neoplastic events. The neoplastic entities -formerly, oncocytic variant of follicular tumours; Hürthle cell neoplasm (HCN) - include HC adenomas and HC carcinomas and have been recognized as a separate class of tumours by the WHO. The remaining of the thyroid tumours demonstrating “mitochondrion-rich cells” and oncocytic morphology are referred under the umbrella term of “oncocytic vari...

ea0032p243 | Clinical case reports – Pituitary/Adrenal | ECE2013

Osteoporotic fractures as manifestation of Cushing’s disease

Nogueira Claudia , Souto Selma , Quinaz Joao , Braga Daniel , Vinha Eduardo , Rios Elisabete , Bernardes Irene , Pereira Josue , Carvalho Davide

Introduction: Cushing’s syndrome (CS) is a well-known cause of bone loss and osteoporotic fractures, which may be the initial manifestation of the disease and may present 2 years before CS diagnosis. Trabecular bone is usually the most seriously affected, and vertebrae and ribs are the typical fracture locations.Case report: A 37-year-old man with dyslipidemia and obesity was observed due to uncontrolled hypertension and osteoporosis. He complained ...

ea0049ep140 | Clinical case reports - Pituitary/Adrenal | ECE2017

Virilization – a non-negligible manifestation of an adrenal tumor

Magalhaes Daniela , Vinha Eduardo , Neves Joao Sergio , Souteiro Pedro , Neves Celestino , Freitas Paula , Maia Jose Costa , Rios Elisabete , Fernandes Ana Catarina , Rodrigues Elisabete , Carvalho Davide

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy with a poor prognosis. Hormone-secreting ACC appear with manifestations of virilization, feminization or Cushing syndrome.Case Report: A 63-year-old woman with no pathological history of relief was referred to Endocrinology evaluation with an history of deepening of the voice since 1-year ago, as well as hair loss and facial and abdominal hirsutism with 6-month evo...

ea0040oc2 | (1) | ESEBEC2016

mTOR pathway activation in papillary thyroid carcinomas: associations and correlations

Tavares Catarina , Coelho Maria , Melo Miguel , Rocha Adriana , Pestana Ana , Batista Rui , Salgado Catarina , Eloy Catarina , Rios Elisabete , Ferreira Luciana , Sobrinho-Simoes M , Soares Paula

Background: Mammalian target of rapamycin (mTOR) is a downstream effector of the PI3K/AKT pathway. It can be activated by diverse stimuli, such as growth factors, nutrients, energy, stress signals and signaling pathways such as PI3K, MAPK and AMPK, in order to control cell growth, proliferation and survival. The active form of mTOR (pmTOR) may form two distinct complexes: mTORC1 that activates S6K1 and 4EBP1 which are involved in mRNA translation; and mTORC2 that activates PKC...

ea0040p4 | (1) | ESEBEC2016

Expression of osteopontin isoforms is related with thyroid cancer growth and invasion

Ferreira Luciana Bueno , Tavares Catarina , Pestana Ana , Leite Catarina , Eloy Catarina , Rios Elisabete , Celestino Ricardo , Batista Rui , Sobrinho-Simoes Manuel , Gimba Etel , Soares Paula

Osteopontin (OPN) is a matricellular protein highly expressed in cancer cells, which is able to modulate tumorigenesis and metastasis in several malignancies, including follicular cell-derived thyroid cancers (TC). OPN is one of the gene products aberrantly expressed in TC, but the contribution of each OPN isoform (OPNi), named as OPNa, OPNb and OPNc, is currently unknown. This study aims to analyze the expression profile of OPNi in TC tissue samples, correlate its expression ...

ea0092op-12-02 | Oral Session 12: Emerging Insights into Thyroid Cancer Genetics | ETA2023

Comparative analysis of somatic copy number alterations (SCNA) between hürthle cell tumors (HCT) and oncocytic variant of follicular cell derived thyroid tumors (OV-FCDTT)

Canberk Sule , Ferreira Marta , Oliveira Carla , Reis Joana , Barros Rita , Pereira Luisa , Osorio Hugo , Rios Elisabete , Paula Arnaud , Soares Paula , Maximo Valdemar

Objectives: Somatic copy number alterations (SCNAs) have been the most common genetic alterations identified in cancer, that frequently related with extensive genomic instability and to an aggressive behavior. Hürthle cell carcinoma is known to be aggressive, having the highest incidence of recurrences, distant metastasis and RAI therapy resistance among all differentiated follicular cell derived thyroid carcinomas. Due to these differences and recent molecular discoverie...

ea0049ep1449 | Thyroid (non-cancer) | ECE2017

The usefulness of the study of sodium iodide symporter expression in thyroid primary tumors

Tavares Catarina , Coelho Maria Joao , Eloy Catarina , Melo Miguel , da Rocha Adriana Gaspar , Pestana Ana , Batista Rui , Ferreira Luciana Bueno , Rios Elisabete , Cavadas Bruno , Pereira Luisa , Selmi-Ruby Samia , Simoes Manuel Sobrinho , Soares Paula

Thyroid cancer therapy is based on surgery followed by radioiodine treatment of tumor remnants and metastases. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS), normally present in thyroid follicular cells’ membrane. We studied the expression of NIS in a series of 229 thyroid primary tumors using real time PCR and immunohistochemistry, and searched for possible associations between NIS expression and clinicopathological feature...