Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep639 | Growth hormone IGF axis - basic | ECE2017

Modulation of the 22 kD/20 kD growth hormone (GH) ratio by exercise, fasting and glucose load in premenopausal women

Haenelt Michael , Schilbach Katharina , Gar Christina , Lechner Andreas , Schwaiger Rita , Bidlingmaier Martin

We previously have shown in a cohort of 236 non-fasted women that before and after a short high intensity exercise protocol (HIP) till exhaustion serum concentrations of 20 and 22 kD growth hormone (hGH) are highly correlated (P<0.0001). Although the GH response to exercise exhibited huge inter-individual differences, the 20 kD/22 kD-GH-ratio remained unchanged (9.6% vs 11.1%, P=0.313). A subgroup of the women was also studied under fasted conditions in a...

ea0049gp196 | Pituitary &amp; endocrine Tumours | ECE2017

Diagnosis of acromegaly: Sex and BMI are the major determinants of growth hormone suppression during oral glucose tolerance test (OGTT)

Schilbach Katharina , Nicolay Shiva Sophia , Haenelt Michael , Lechner Andreas , Gar Christina , Schopohl Jochen , Stormann Sylvere , Schwaiger Rita , Bidlingmaier Martin

GH suppression during OGTT is the gold-standard test in diagnosis and monitoring of acromegaly. However, discrepancies between GH nadir and IGF-I have been described and have triggered search for factors modifying the extent of GH suppression. Cut-offs at 1.0 or 0.4 ng/ml are currently recommended with modern, highly sensitive GH assays. To establish assay specific GH nadir cutoffs for the 22kD GH specific IDS-iSYS assay, we examined 381 subjects (319 females, 62 males) with n...