Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc5.2 | Adrenal 1 | ECE2019

Pheochromocytoma aggressiveness induced by tumor microenvironment depends on the SDH subunit involved

Martinelli Serena , Riverso Maria , Mello Tommaso , De Filpo Giuseppina , Canu Letizia , Maggi Mario , Mannelli Massimo , Rapizzi Elena

Pheochromocytoma/paraganglioma (Pheo/PGL) are rare neuroendocrine tumors generally benign. About 30–40% of Pheo/PGL are due to germ-line mutations in one of the susceptibility genes, including those encoding the succinate dehydrogenase subunits A-D (SDHA-D). Up to 80% of patients affected by SDHB mutated Pheo/PGL develop metastatic disease with no successful cure at present. In this study, we evaluated the different effect of tumor microenvironment on tu...