Endocrine Abstracts

Background: A growing body of evidence reports implications of a direct extra-gonadal effect of follicle stimulating hormone (FSH), involving the development of obesity. The aim of this study was to evaluate the associations between traditional and local obesity indices and FSH concentrations in women after menopause.Methods: We evaluated a total of 420 postmenopausal women in a cross-sectional design (age 55.6±6.5 years, BMI were 25.8±4.0 kg/m...

Objective: Aiming to identify individuals with more benign metabolic profile, we explored the link between anthropometric predictors as well as serum levels of sex hormones and phenotypes of metabolic health in non-obese postmenopausal women.Methods: A total of 458 non-obese (BMI <30 kg/m2) postmenopausal women (age 55.2±7.1 years, BMI=24.6±2.8 kg/m2) were retrieved from the Menopause Clinic of Aretaieio Hospital, Nati...

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.Design: Randomized, double-blinded study.Patients: One hundred healthy postmenopausal women.Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2</...

Background: Both surgical and spontaneous menopause are associated with increased cardiovascular disease (CVD) risk. Recent evidence reported that clusters of menopausal symptoms are associated with accumulation of cardiometabolic risk factors. Climacteric symptoms are also known to be affected by lifestyle parameters, ethnicity, the geographical location as well as by the overall health status at the time of the menopausal transition.Aim: This study aim...

Introduction: Differences in the prevalence and prognosis of cardiovascular disease have been linked with gender specific risk factors as well as the differential impact of sex hormones. Moreover, specific genetic polymorphisms may increase further the risk of cardiovascular disease development. Polymorphisms of genes encoding the NADPH/NADPH oxidase system and the endothelial nitric oxide synthase (eNOS) have been associated with atherosclerosis in the general population, but...

Introduction: The prevalence of cardiovascular disease in reproductively active women has received limited attention. Recent data indicated possible adverse effect of non-typical obstetrical risk factors with regards to cardiovascular function. We aimed to evaluate the potential association between anti-mullerian hormone (AMH), a known marker of ovarian reserve, with subclinical atherosclerosis in young premenopausal women.Methods: This was a cross-secti...

Introduction: Thyroid dysfunction, whether overt or subclinical, has a significant effect on the cardiovascular system. On the other hand, fluctuation of thyroid hormones within the normal range has been associated with long-term health risks, and might have an impact on the vasculature. This study assessed the effect of thyroid hormones on surrogate markers of arterial structure and function in a sample of euthyroid postmenopausal women.Methods: This cr...

Objective: To investigate the effect of BMI on the absolute change from baseline levels in circulating sex hormone in postmenopausal women treated with oral continuous combined low dose HT for 6 months.Design: The study recruited 36 postmenopausal women who received daily E2 1 mg/NETA 0.5 mg for 6 months. Hormonal assessment included measures of serum concentrations of FSH, LH, 17β-estradiol and free estrogen index (FEI), total and free testosterone...

Background: Postpartum mood disturbances occur very often in otherwise healthy women, whereas thyroid function is affected during a normal pregnancy. We examined whether thyroid hormone levels in women free from thyroid dysfunction associate with the prevalence of postpartum mood disturbances.Methods: This cross-sectional study included 57 Greek women. Concentrations of thyroid hormones (free T3, free T4, TSH) and anti...

Background: Heat shock protein 60 (HSP60), a potentially homeostatic antigen, has been shown to be involved in physiological and non-physiological conditions. Experimental data is supporting the role of HSP60 in placental and mitochondrial steroidogenesis. Under stress conditions, HSP60 are translocated into the endothelial-cell plasma membrane and the extracellular space, promoting the atherosclerotic process. Aim: We decided to investigate the associat...