Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1092 | Developmental endocrinology | ECE2017

Age and developmental stage dependent relationship between plasma concentrations of leptin, luteinizing hormone, follicle stimulating hormone, prolactin, testosterone and inhibin B in boys between the age of 1 and 20 years

Naseem Afzaal Ahmed , Qayyum Mazhar , Akram Maleeha , Iqbal Zubaria , Tahir Fahim , Afshan Kiran , Jahan Sarwat , Rizvi Syed Shakeel Raza

Leptin is regarded as an essential adipokine for controlling energy homeostasis, caloric intake reduction and increase of caloric expenditure by negative feedback mechanisms via receptors in the hypothalamus. Puberty is said to be triggered by leptin, which signals the hypothalamus that adequate fat reserves are available for initiation of energetically costly process of reproduction. Leptin activates gonadotropin releasing hormone (GnRH) system, which stimulates luteinizing h...

ea0049ep1225 | Paediatric endocrinology | ECE2017

Age and development stage dependent association between thyroid hormones and growth hormone and linear growth velocity in boys between the age of 1 and 20 years

Naseem Afzaal Ahmed , Qayyum Mazhar , Akram Maleeha , Iqbal Zubaria , Tahir Faheem , Jahan Sarwat , Afshan Kiran , Rizvi Syed Shakeel Raza

During the time of puberty, thyroid hormones (THs), thyroxin (T4) and triiodothyronine (T3), influence growth and developmental processes by working in association with growth hormone (GH), insulin like growth factor-I (IGF-1), glucocorticoids, insulin and gonadal steroids. THs have a direct effect on GH secretion, which stimulates IGF system. It has been suggested that THs control increase in bone length through synergy with GH. This investigation determ...

ea0063p456 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

An investigation into the role of parathyroid hormone in the regulation of aldosterone secretion in hypertensive cardiovascular patients

Jannat Saba , Akram Maleeha , Jahan Sarwat , Kazmi Ali Raza , Afshan Kiran , Tahir Fahim , Naseem Afzaal Ahmed , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Hypertension or elevated blood pressure (BP) is quantitatively the most important risk factor for development of cardiovascular diseases (CVDs), whereas aldosterone contributes significantly in the development and severity of hypertension. Interestingly, parathyroid hormone (PTH) stimulates aldosterone synthesis by regulating renin-angiotensin-aldosterone system (RAAS). Conversely, RAAS controls PTH secretion, as angiotensin receptor is expressed by human parathyroid tissues a...

ea0063p892 | Diabetes, Obesity and Metabolism 3 | ECE2019

An investigation into the relationship between plasma concentrations of cortisol, testosterone, blood pressure and blood glucose levels in diabetic hypersensitive cardiovascular patients

Ullah Safir , Rafi Muhammad , Akram Maleeha , Kazmi Ali Raza , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

Diabetes mellitus type 2 (DM-2) occurs when pancreas fails to produce enough insulin or when the body cannot effectively make use of the insulin produced by the pancreas. Among other factors causing DM-2, stress is increasingly regarded as one of the causative agents that make the blood glucose levels rise, and cause DM-2. It has also been reported that DM-2 may be one of the commonest cause of hypogonadism, a lack of function in the testes, which adversely affects testosteron...

ea0063ep3 | Adrenal and Neuroendocrine Tumours | ECE2019

Depression and anxiety are positively correlated with higher concentrations of cortisol and blood pressure in hypertensive cardiovascular disease patients

Unab Shiza , Akram Maleeha , Tahir Fahim , Jahan Sarwat , Kazmi Ali Raza , Afshan Kiran , Naseem Afzaal Ahmed , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Hypertension or high blood pressure (HBP) has been counted as the chief cause and most significant factor in the development of cardiovascular diseases (CVDs) worldwide. Stress has been defined as an inner process that happens when a person is faced with an ordinant dictation that is perceived to go beyond the resources available to efficaciously respond to it. Cortisol is a hormone released from the zona fasciculata of the adrenal cortex during the times of stress. This biolo...

ea0041ep468 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Earlier development of diabetes mellitus type 2 as a consequence to psychological and physiological stress

Shaheen Samrah , Akram Maleeha , Jahan Sarwat , Raja Ghazala Kokab , Kazmi Syed Ali Raza , Raza Abida , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

Diabetes mellitus type 2 (DM-2) is a disorder characterized by high blood glucose levels in the context of insulin resistance and relative insulin deficiency. DM-2 is typically an outcome of combinations of hereditary elements of impaired insulin release and insulin resistance, and natural variables like obesity, overeating, absence of activity, aging and stress. A number of hormones, such as cortisol and growth (GH), have insulin-antagonistic effects. Cortisol is a predominan...

ea0041ep717 | Male Reproduction | ECE2016

Delay in the onset of male puberty: role of mutations in luteinizing hormone-beta gene

Shaheen Ghazala , Akram Maleeha , Mansoor Qiaser , Ismail Muhammad , Ishtiaq Osama , Jahan Sarwat , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

The reawakening of hypothalamo-pituitary-gonadal axis at puberty is influenced by a number of hormonal and genetic factors along with certain environmental cues. In boys, puberty is initiated at around 9 years of age as plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) begin to rise leading to development of secondary sex characteristics. The absence of signs of sexual maturation at the age of 14/15 years is regarded as ...

ea0073aep594 | Reproductive and Developmental Endocrinology | ECE2021

C173R and R273W mutations but not P108L in growth hormone secretagogue receptor 1a (GHSR1a) gene may cause short stature in Pakistani children

Kausar Nighat , Akram Maleeha , Shahid Gulbin , Naseem Afzaal Ahmed , Qayyum Mazhar , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Rizvi Syed Shakeel Raza

The combined physiological effects of somatotropic and gonadal axes have been demonstrated to cause acceleration in linear growth at puberty. In synergy, growth hormone (GH) and gonadal steroids (testosterone [T] and estradiol [E2]) stimulate longitudinal bone growth through direct stimulation of chondrocytes and osteoblasts. Amongst others, the secretion of GH is stimulated by ghrelin through its receptor called GH secretagogue receptor 1a (GHSR1a). Ghrelin is a peptide secre...

ea0063p1160 | Thyroid 3 | ECE2019

Stress induced cortisol release depresses the secretion of triiodothyronine in patients with anterior wall myocardial infarction

Javid Muhammad , Kayani Amjad Rashid , Akram Maleeha , Kazmi Ali Raza , Jahan Sarwat , Afshan Kiran , Rauf Sania , Naseem Afzaal Ahmed , Tahir Fahim , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Stress is any uncomfortable emotional experience accompanied by predictable psychological, physiological and behavioral changes. A sudden and severe stress generally produces an increase in the heart rate and blood pressure and induces a state of alertness in an individual. Evidence indicates that chronic stress depresses thyroid function, resulting in low levels of T3 and T4, which affects cardiomyocytesÂ’ function and leads to development of cardiov...

ea0049ep205 | Paediatric endocrinology | ECE2017

An analysis of R356W and Q318X mutations and 8 bp deletion in 21-hydroxylase gene CYP21A2 in causing pseudo-precocious puberty in patients with congenital adrenal hyperplasia in Pakistani children

Parveen Nadiaj , Minallah Samar , Ismail Muhammad , Mansoor Qaiser , Akram Maleeha , Iqbal Zubaria , Jahan Sarwat , Afshan Kiran , Shahid Gulbin , Tahir Faheem , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

The first signs of puberty are visible around the age of 8 years in girls and 9 years in boys. If signs of puberty appear before the designated ages in girls and boys, puberty is viewed as precocious. In peripheral precocious puberty, androgens concentrations increase due to testicular tumours or congenital adrenal hyperplasia (CAH). Two mutations, R356W and Q318X, and one 8 bp deletion in CYP21A2 gene, causing CAH type of precocious puberty were examined. Blood samples were o...