Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep54 | Adrenal cortex | ECE2015

A phase 1, randomised, open-label, four-period crossover, single-dose study to evaluate the pharmacokinetics of hydrocortisone modified release tablets

Johannsson Gudmundur , Lennernas Hans , Marelli Claudio , Rockich Kevin , Skrtic Stanko

Novel biopharmaceutical techniques have allowed the development of a hydrocortisone modified release (MR) tablet (once-daily administration for replacement therapy in adrenal insufficiency) mimicking more closely the physiological serum cortisol profile. Robust bioavailability is needed to secure this new treatment safety.Aims: To compare single-dose pharmacokinetics (PK) of MR tablets manufactured at two different sites by assessing intra-subject variab...