Searchable abstracts of presentations at key conferences in endocrinology

ea0081p659 | Pituitary and Neuroendocrinology | ECE2022

Evaluation of copeptin levels during glucagon stimulation test in children with suspected growth hormone deficiency

Ferrante Emanuele , Giacchetti Federico , Indirli Rita , Profka Eriselda , Rodari Giulia , Giavoli Claudia , Mantovani Giovanna , Arosio Maura

Introduction: Glucagon stimulation test is one of the recommended growth hormone provocation tests for diagnosing growth hormone deficiency in children. In adult patients, recent data showed that glucagon administration is able to stimulate the release of copeptin, the stable C-terminal glycopeptide of the AVP prohormone whose evaluation during hypertonic saline infusion represents the gold standard for the differential diagnosis of polyuria/polydipsia. However, similar data o...

ea0090rc4.6 | Rapid Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Bone and sexual health in adult women with complete androgen insensivity syndrome: A single centre experience

Profka Eriselda , Rodari Giulia , Giacchetti Federico , Giavoli Claudia , Arosio Maura , Mantovani Giovanna

Background: Low bone mineral density (BMD) and reduced sexual satisfaction have been reported in complete androgen insensitivity syndrome (CAIS). Nevertheless, conclusive data on the prevalence and on the optimal management of these conditions are still lacking.Aims: To assess bone and sexual health in adult women with CAIS with and without gonadectomy.Methods: Single-centre, prospective study of 27 adult CAIS (age 35.2±8.7 ye...

ea0090p453 | Reproductive and Developmental Endocrinology | ECE2023

In between isolated premature thelarche and central precocious puberty: when DHEAS makes the difference

Rodari Giulia , Collini Valentina , Giacchetti Federico , Profka Eriselda , Arosio Maura , Mantovani Giovanna , Giavoli Claudia

Background: Precocious puberty (PP) in girls is most frequently an idiopathic gonadotropin-releasing hormone (GnRH)-dependent PP, being thelarche the typical first sign. It is well established that increased dehydroepiandrosterone sulphate (DHEAS) levels are associated with premature adrenarche and may characterize PP too. However, its relationship with signs of hypothalamic-pituitary-gonadal (HPG) axis activation and oestrogen exposure is still to be elucidated.<p class="...

ea0070aep571 | Pituitary and Neuroendocrinology | ECE2020

Deletion of chromosome 1q24-1q32 and combined pituitary hormone deficiency type 4: Insight into the challenges of genotype-phenotype correlation

Giavoli Claudia , Ubertini Graziamaria , Giacchetti Federico , Rodari Giulia , Profka Eriselda , Cianfarani Stefano , Arosio Maura , Cappa Marco

Background: Interstitial deletions of the long arm of chromosome 1 are rare and classified as proximal or intermediate, the intermediate spanning bands 1q24–1q32. This region contains several genes, including LHX4, a LIM-homeodomain transcription factor essential in the early steps of pituitary ontogenesis. Indeed, mutations in the LHX4 gene are related to combined pituitary hormone deficiency type 4 (CPHD4, OMIM 602146).Aim: outline the impact of ...

ea0070aep572 | Pituitary and Neuroendocrinology | ECE2020

Baseline IGF-I values influence the effect of rhGH therapy on fat mass: Short, medium and long term study on adults with GH deficiency

Profka Eriselda , Rodari Giulia , Giacchetti Federico , Draghi Alessandro , Arosio Maura , Giavoli Claudia

Background: One of the main effects of growth hormone therapy (rhGH) in the adult GH deficient patient (AGHD) is to positively modify body composition, with a reduction in fat mass (BF) and an increase in total lean mass (LM). However, the response to replacement therapy is highly variable and, contrary to what described in children, the potential predictive factors are not yet known.Aim of the study: To assess the impact of basal IGF-I levels on variati...

ea0070aep765 | Pituitary and Neuroendocrinology | ECE2020

Controversies in the spectrum of GH-IGF-I axis disorders requiring replacement therapy

Rodari Giulia , Cavenaghi Ivan , Profka Eriselda , Giacchetti Federico , Arosio Maura , Giavoli Claudia

Background: Growth hormone deficiency (GHD) is the most frequent endocrinological disorder inchildren with short stature, but there are significant controversies in the diagnosis due to lack of reliablediagnostic criteria. Moreover, at final height (FH) attainment, many subjects diagnosed withisolated GHD re-test normal. It is not clear whether this represents a form of transient GHD or a false positive diagnosis during childhood.Aim: To evaluate differe...

ea0081rc12.7 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Pubertal induction in girls with hypogonadism: insight into estrogen replacement therapy outcomes and optimization of progesterone introduction

Rodari Giulia , Federici Silvia , Cattoni Alessandro , Todisco Tommaso , Ubertini Graziamaria , Giacchetti Federico , Profka Eriselda , Dall'Antonia Alberta , Cangiano Biagio , Arosio Maura , Bonomi Marco , Cappa Marco , Giavoli Claudia

Background: Pubertal induction in girls with hypogonadism through estrogen replacement therapy (ERT) aims at mimicking physiological puberty. To date, the best induction regimen is still to be established.Aims: By setting up a multicentre clinical registry, we analysed longitudinal data on pubertal induction in girls with hypogonadotropic hypogonadism or premature ovarian insufficiency (congenital, acquired, isolated or associated with multiple pituitary...

ea0081oc4.2 | Oral Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Measurements of growth hormone in neonatal screening cards as a non-invasive and feasible tool: reference values in healthy term newborns

Giacchetti Federico , Vidali Matteo , Sangiorgio Andrea , Rodari Giulia , Vantaggiato Chiara , Di Modugno Adriana , Morniroli Daniela , Colombo Lorenzo , Profka Eriselda , Dall'Antonia Alberta , Mosca Fabio , Ceriotti Ferruccio , Arosio Maura , Gianni' Maria Lorella , Giavoli Claudia

Background: Severe congenital growth hormone deficiency (cGHD) is a rare but potentially life-threatening condition. Even though random growth hormone (GH) can confirm cGHD during the first week of life, the diagnosis remains extremely challenging in the absence of reliable reference values in healthy neonates and thus of a best diagnostic cut-off.Aims: First, to provide solid reference values for GH concentrations in term newborns, by means of a non-inv...

ea0070aep1005 | Hot topics (including COVID-19) | ECE2020

Adrenal insufficiency at the time of COVID-19: A retrospective study

Carosi Giulia , Morelli Valentina , Del Sindaco Giulia , Cremaschi Arianna , Frigerio Sofia , Rodari Giulia , Indirli Rita , Liliana Serban Andreea , Profka Eriselda , Mungari Roberta , Resi Veronica , Orsi Emanuela , Ferrante Emanuele , Dolci Alessia , Giavoli Claudia , Arosio Maura , Mantovani Giovanna

Background: COVID-19 represents a global health emergency and infected patients with chronic diseases often present a severe impairment. Adrenal insufficiency (AI) is supposed to be associated with an increased risk of infections which could trigger adrenal crisis. Our primary aim was to evaluate the incidence of COVID-19 symptoms and complications in AI patients.Materials and methods: We conducted a retrospective case-control study, in 279 patients with...

ea0090oc3.4 | Oral Communications 3: Pituitary and Neuroendocrinology 1 | ECE2023

Measurements of growth hormone using dried blood spots in preterm neonates: reference values and longitudinal evaluation.

Giacchetti Federico , Vidali Matteo , Orsenigo Chiara , Vizzari Giulia , Tarricone Silvia , Vantaggiato Chiara , Rodari Giulia , Modugno Adriana Di , Napolitano Filomena , Sangiorgio Andrea , Morniroli Daniela , Colombo Lorenzo , Profka Eriselda , Collini Valentina , Gianni Maria Lorella , Mantovani Giovanna , Mosca Fabio , Ceriotti Ferruccio , Arosio Maura , Giavoli Claudia

Background and Aim: Congenital growth hormone deficiency (cGHD) is a rare but life-threatening condition whose diagnosis is challenging in the absence of reliable reference values, both in healthy neonates and in preterm ones. We recently estimated GH reference interval in 1036 healthy, at-term newborns (HN) form dried blood spot samples using a previously validated analytical method. Aim of this study is to provide values for random GH in preterm newborns (PN).<p class="a...