Searchable abstracts of presentations at key conferences in endocrinology

ea0063p640 | Interdisciplinary Endocrinology 1 | ECE2019

Different regulation of erythropoietin and VEGF in clear renal cell carcinoma

Cokic Bojana Beleslin , Macut Djuro , Milicevic Ivana , Rodic Gordana , Bankovic Jovana , Antic Jadranka , Noguchi Constance , Damjanovic Svetozar

Clear renal cell carcinoma (ccRCC) is a highly vascularized and proliferative tumor. ccRCC can be sporadic or familiar, usually associated with von Hippel-Lindau (VHL) gene mutations. VHL protein is part of the E3 ubiquitin ligase complex that regulates hypoxia-inducible factor (HIF). When a defective and inactive VHL protein is produced, HIF is not degraded, resulting in over-expression of hypoxia related genes including erythropoietin (EPO) and vascular endothelial growth fa...

ea0070aep534 | Endocrine-related Cancer | ECE2020

Diverse regulation of HIF-1 on VEGF in renal cell carcinoma

Beleslin Cokic Bojana , Damjanovic Svetozar , Bizic Radulovic Sandra , Suboticki Tijana , Cokic Vladan , Milicevic Ivana , Rodic Gordana , Antic Jadranka , Macut Djuro

The clear cell renal cell carcinoma (ccRCC) can be sporadic or familiar, with the mutated von Hippel-Lindau (VHL) gene. The inactive VHL protein prevents degradation of hypoxia inducible factor (HIF) that promotes overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO). Sequencing and multiplex ligation-dependent probe amplification (MLPA) of VHL gene in 43 samples of ccRCC in tumors vs surrounding healthy tissues reveale...

ea0049ep191 | Endocrine tumours and neoplasia | ECE2017

Biology and differential diagnosis of calcitonin secreting neuroendocrine tumors

Popovic Bojana , Macut Djuro , Elezovic Kovacevic Valentina , Isailovic Tatjana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Ognjanovic Sanja , Rodic Gordana , Petakov Milan , Damjanovic Svetozar

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

ea0037ep1141 | Endocrine tumours | ECE2015

Genotype–phenotype analysis in patients with medullary thyroid carcinoma: a single centre experience

Isailovic Tatjana , Rodic Gordana , Macut Djuro , Petakov Milan , Ognjanovic Sanja , Elezovic Valentina , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Introduction: Medullary thyroid carcinoma (MTC) is a malignant neoplasm derived from the parafollicular cells of the thyroid gland. Approximately 25% of them are caused by germline mutations of the RET gene, presenting as a part of FMTC, MEN2A or MEN2B syndrome.Design of the study: We analysed 213 consecutive patients with MTC (142 females, 71 males, age 6–78, mean 45 years), treated in a single centre from 2004 to 2014. Direct DNA sequenci...