Endocrine Abstracts

Introduction: MEN4 syndrome is a recently described form of MEN in patients with parathyroid and anterior pituitary tumors, which may also develop bronchial, gastric and pancreatic neuroendocrine tumors. In general, the patients present with clinical signs of primary hyperparathyroidism and simptoms caused by pituitary hormones hypersecretion or due to the tumor mass. However, clinical cases with the coexistence of pituitary tumors and pheochromocytoma are very rare described....

Introduction: Synovial sarcoma represents a type of cancer derived from soft tissues; young males are more affected.Material and methods: This is a case report of a male with a cervical mass confirmed as sarcoma. Later on the investigations lead to the discovery of a thyroid nodule challenging the differential diagnosis. We assessed thyroid ultrasound, computed tomography (CT) at the cervical, thorax, mediastinum and abdomen; TSH (Thyroid Stimulating Hor...

Introduction: We should consider testing for primary aldosteronism in the presence of hypertension and hypokalaemia, resistant hypertension, onset of hypertension at a young age (<20 year), severe hypertension and whenever considering secondary hypertension.Case report: We presented the case of a 38 years old woman who was admitted in the National Institute of Endocrinology C.I. Parhon Bucharest for the evaluation of high blood pressure. She has high...

Catecholamines can cause hypertension by increasing heart rate and cardiac output or by peripheral vasoconstriction.Aim of study: The value of plasma and urinary metanephrines and normetanephrines does not correlate with blood pressure in pheochromocytomas.Material and methods: The lot of study consist of 35 patients with isolated pheochromocytomas diagnosed between 1985 and 2005 in National Institute of Endocrinology C.I.Parhon Bu...

Introduction: The pituitary non-secreting microadenomas (or incidentalomas) are frequently diagnosed over the last decades thanks to imagery scan progresses and access. The gonadal dysfunction, as well as other pituitary deficiency is related to common genetic backup (+/− other pituitary dysfunctions) or may be incidental.Aim: We analyzed the endocrine profile in pituitary incidentalomas (microadenomas).Material and method: A...

Introduction: There are many side effects caused by mitotane and several are registered at drug levels lower than therapeutical doses.Aim: We observed the mitotane side effects in patients treated for adrenal cancer.Materials and methods: This is a retrospective study in adrenal tumors.Results: Out of 56 patients included in a database with adrenal tumors, we found eight patients (14.25%) with adrenal cancer ...

We presented the case of a 20-year-old woman which has presented for endocrinologic evaluation after right adrenalectomy for pheochromocytoma. From her heredocolateral antecedents, we retain her grandmother and sister of her father with sudden cardiac death at early age. At this presentation, she had normal plasma and urinary MN and NMN. Plasma Cg A and Serotonin are normal and the CT exam showed right adrenalectomy and right renal microlitiasis. Genetic analysis showed mutati...

Because of the increased prevalence of thyroid disorders in Romania we realized a retrospective study in which we followed the variance of TSH, function of temperature, in different seasons. In this context, based on TSH value we appreciated the need of thyroid hormones and antithyroid drugs to maintain an euthyroid state.Material and methods: The group of study consist of 634 patients, men and women over 18-years-old with thyroid disorders: hypo, hyper,...

Introduction: Thyroid cancer incidence has registered an important increase in the last years. Anaplastic thyroid cancer represent a rare malignancy with an aggressive biological behavior and a high mortality rate.Case presentation: We present the case of a 69-years-old woman who addressed our department for endocrine evaluation in the context of a right latero-cervical lymph nodes, complaining of mixed dysphagia and dyspnea, that developed progressively...

Introduction: The Cushing’s syndrome associated bilateral adrenal tumours comprise a wide area of diagnosis; the therapeutic approach is challenging since unilateral intervention might involve persistent hypercotisolemia, and bilateral adrenalectomy induces chronic adrenal insufficiency. The adrenal vein catheterism is not available in many countries.Case report: 50-year old non-smoker female has the following medical history: 2 years ago she presen...