Searchable abstracts of presentations at key conferences in endocrinology

ea0022s26.1 | Adverse effects of drugs on thyroid | ECE2010

Tyrosine kinase inhibitors and thyroid

Rodien Patrice

The use of targeted therapies such as Tyrosine kinase inhibitors is becoming a common strategy in several advanced cancers. Several tyrosine kinases are targeted by the drugs, and the anti-neoplastic actions involves both anti-proliferative and anti-angiogenesis effects. Initial case reports, have been followed by series reporting treatment induced thyroid dysfunctions. They include thyrotoxicosis and hypothyroidism sometimes with a biphasic course, reminiscent of silent subac...

ea0063gp231 | Adrenal and Neuroendocrine - Clinical (1) | ECE2019

In vitro effects of bisphenol A and its analogs on human melanocortin 4 receptor

Louvigne Mathilde , Gourdin Louis , Briet Claire , Rodien Patrice , Munier Mathilde

Bisphenol A (BPA) is a widely used chemical and belongs to the list of metabolism-disrupting chemicals. BPA is banned in several countries and replaced by others BPA-analogs. We investigate the effects of BPA and 6 BPA-analogs (BPS, BPAF, BPF, BPB and BADGE) on the response of the human melanocortin 4 receptor (MC4R), a receptor involved in food intake and weight control, to its natural ligands. We used HEK293 cells line transiently transfected with human MC4R to determine the...

ea0063p1000 | Environment, Society and Governance | ECE2019

In vitro effects of the endocrine disruptors DEHP, DBP and BPA on INSL3 receptor (RXFP2)

Suteau Valentine , Gourdin Louis , Briet Claire , Rodien Patrice , Munier Mathilde

Introduction: Epidemiological and In vivo experimental studies reveal reprotoxic effects of endocrine disruptors (phthalates (DBP, DEHP) and bisphenol A (BPA)). An inverse association was found between the concentration of these endocrine disruptors and the concentration of INSL3. INSL3, a relaxine peptide, is involved in reproductive function, via its cognate receptor, RXFP2. The aim of this study was to characterize the involvement of RXFP2 in the effects o...

ea0063p639 | Interdisciplinary Endocrinology 1 | ECE2019

Constitutive activity of human RXFP2

Suteau Valentine , Gourdin Louis , Briet Clairee , Lebeault Maylis , Rodien Patrice , Munier Mathilde

Introduction: The relaxin family peptide receptor 2 (RXFP2) is the receptor for Insulin-like peptide-3 (INSL3). The INSL3/RXFP2 signaling is necessary in the first stage of testis descent. Besides, it is proposed that RXFP2 has a role in bone metabolism or in development of cancers (thyroid, prostate). RXFP2 is a rhodopsin-like G protein-coupled receptors (GPCR). Recently, it has been demonstrated that Drosophila RXFP2 had constitutive activity, i.e., a ligand-independent sign...

ea0063p1001 | Environment, Society and Governance | ECE2019

Halogenous derivatives of Bisphenol A inhibit the human FSH receptor activity

Sibilia Paul , Doumas Manon , Gourdin Louis , Briet Claire , Carato Pascal , Rodien Patrice , Munier Mathilde

Numerous epidemiological studies link exposure to Bisphenol A (BPA) to reproductive function anomalies. Our team recently showed that BPA inhibits the action of Follicle Stimulating Hormone (FSH) on its receptor (FSHR). Water decontamination is achieved by chloration, which leads to the formation of chlorinated derivatives of Bisphenol A (ClXBPA), that may be found in natural environments and biological liquids or organs. In the presence of bromine, the formation of...

ea0063p1049 | Pituitary and Neuroendocrinology 3 | ECE2019

Expression of programmed death ligand 1 (PD-L1) in human pituitary adenomas

Suteau Valentine , Collin Alexandre , Menei Philippe , Rodien Patrice , Rousselet Marie-Christine , Briet Claire

Introduction: Pituitary adenomas, second most common brain tumors, are mostly well controlled after surgery. However, some pituitary tumors present an aggressive evolution and are resistant to standard management. Immunotherapy with inhibitors of T-cell checkpoints have shown durable efficacy in a variety of malignancies. Moreover, immunotherapy has been associated with treatment-related hypophysitis, suggesting that pituitary could be a target of these treatments. Recently, i...

ea0016p36 | Adrenal | ECE2008

Aberrant cortisol responses in adrenal incidentalomas: a study on evaluation and management of 20 patients

Priou Melanie , Busson Catherine Draunet , Illouz Frederic , Hamy Antoine , Schinkel Elsa Parot , Rodien Patrice , Rohmer Vincent

In overt or subclinical ACTH-independant Cushing’s syndrome (CS), aberrant adrenal receptors may control cortisol secretion.We systematically studied the 20 patients with adrenal incidentaloma screened in our department for illegitimate adrenal receptors between 2000 and 2006. We investigated plasma cortisol level during successive stimulation tests performed while dexamethasone was given orally every 8 h (upright posture, meal, hypothalamic hormone...

ea0063oc4.4 | Thyroid 1 | ECE2019

Cardiac and vascular characteristics of thyroid hormone resistance syndrome in France

Sibilia Paul , Briet Claire , Prunier-Mirebeau Delphine , Moal Valerie , Bouhours-Nouet Natacha , Coutant Regis , Rodien Patrice , Illouz Frederic

Introduction: The syndrome of reduced sensitivity to thyroid hormone (SRSTH) due to mutations of thyroid hormone receptor β (TRB) consists of an inappropriate secretion of TSH with elevated levels of thyroid hormones. Cardiovascular manifestations are often the ones that affect patients. Our aim was to evaluate the cardiac and vascular characteristics of patients with SRSTH due to TRB mutations.Materials and methods: We analysed cl...

ea0049gp143 | Male Reproduction and Endocrine Disruptors | ECE2017

In vitro effects of Bisphenol A on two metabolic receptors signaling: MC4R and FFAR1

Munier Mathilde , Louvigne Mathilde , Rudelle Helene , Gourdin Louis , Briet Claire , Henrion Daniel , Chabbert Marie , Coutant Regis , Rodien Patrice

Metabolic diseases (type 2 diabetes (T2D) and obesity) prevalence is increasing in the world. This is partly related to a change in lifestyle with an increase of caloric intake and a decrease of physical activity. Environmental causes are also involved among them exposure to bisphenol A (BPA). The mode of action of the latter is unknown. Beyond a suggesting effect relayed by nuclear receptors, we propose that BPA can act by modulating the functionality of G protein-coupled rec...

ea0063p1198 | Thyroid 3 | ECE2019

Radioiodine-avid bone metastases from differentiated thyroid cancer without structural abnormality, a singular entity with heterogeneous outcomes

Marx Claire , Mele Luciana , Decaussin-Petrucci Myriam , Descotes Francoise , Echallier Pierre-Yves , Lopez Jonathan , Martin Eric , Oliel Myriam , Rodien Patrice , Borson Chazot Francoise , Bournaud Claire

Bone radioiodine (RAI) uptake without structural abnormality in thyroid cancer (TC) patients may be related to false positive or to microscopic foci of metastatic tissue. In such cases, outcome is reported to be excellent. Mrs D. had been operated for a pT3(m) poorly differentiated TC at the age of 43. The first post-therapeutic whole body scan revealed 3 foci of bone uptake (right clavicle, L2, L3). The elevated level of thyroglobulin (157 ng/mL) favoured the hypothesis of bo...