ea0086oc5.1 | Metabolism, Obesity and Diabetes | SFEBES2022
Suchacki Karla
, Ramage Lynne
, Gray Calum
, Rodrguez Blanco Giovanny
, Choong Kwok T'ng
, Boyle Luke
, MacNaught Gillian
, Gregoriades Maria-lena
, Wakelin Sonia
, von Kriegsheim Alex
, Finch Andrew
, Patel Dilip
, van Beek Edwin
, Stimson Roland
Background: 18F-fluorodeoxyglucose (18FDG) PET is commonly used to quantify brown adipose tissue (BAT) mass/activity in humans but requires cold exposure. Rodent brown (BAds) but not white adipocytes (WAds) exhibit high choline content, thus we hypothesised that human BAT would demonstrate substantial 18F-fluorocholine (18FCH) uptake in vivo during warm and cold conditions.Methods: (1)...