Endocrine Abstracts

Introduction: The major clinical importance of 17-OH-Progesterone is related to the diagnosis and therapeutic monitoring of Congenital Adrenal Hyperplasia (CAH). Radioactive assays are widely used in clinical laboratories for measuring 17-OH-Progesterone. The appearance of a non-isotopic, chemiluminescent automatic assay, may be an interesting alternative if the performance of the assay remains the same or higher.Obective: To compare the 17-OH-Progestero...

Introduction: Radioactive assays are widely used in clinical laboratories for measuring free testosterone. The appearance of a non-isotopic, chemiluminescent automatic assay, may be an interesting alternative if the performance of the assay remains the same or higher.Objective: To compare the free testosterone results by radioimmunoassay (RIA) and chemiluminescent assay (CLIA) and to analyze the clinical impact taking into account the % concordance.<...

Introduction: IGF-I is a clinically relevant protein in the diagnosis and monitoring of treatment of growth disorders. The Growth Hormone Research Society and the International IGF Research Society have encouraged the adoption of a universal calibration for immunoassays to improve standardization of IGF-I measurements.Objectives: Comparison of new standardization IGF-I assay with IGF-I assay currently used in CHLC, Lisbon; To study whether the introducti...

Introduction: Anti-TSH receptors (TRAb) are an important marker in the differential diagnosis of the etiologies of hyperthyroidism. They detect serum TSH receptor immunoglobulins that interact with the TSH receptor without the functional discrimination of stimulating from blocking antibodies. A new assay has recently been released, that utilizes recombinant human TSH receptors (hTSHR) for the specific detection and quantification of thyroid stimulating autoantibodies (TSI).</p...

Introduction: The presence of anti-thyroglobulin antibodies (ATG) can induce falsely lower thyroglobulin (Tg) values. The methods characteristics used for ATG measurement vary according to the equipment/reagent used. ATG at our centre is measured by Unicap.Objective: To assess if patients with negative ATG by Unicap® have different results with other equipment.Methods: A cross-sectional retrospective study was condu...