Searchable abstracts of presentations at key conferences in endocrinology

ea0049oc1.2 | Adrenal-Basic & Clinical | ECE2017

EZH2: a master regulator of adrenal cortex homeostasis and zonation

Mathieu Mickael , Drelon Coralie , Tabbal Houda , Rodriguez Stephanie , Septier Amandine , Berthon Annabel , Sainte-Catherine David , Breault David , Martinez Antoine

In adult mice the adrenal cortex is divided, in two distinct functional zones, outermost zona glomerulosa (ZG) and innermost zona fasciculata (ZF), encapsulated by a thin layer of mesenchymal cells (capsule). The adrenal cortex undergoes constant centripetal cell renewal, reliying on recruitment of progenitors located within an outer cortex niche. Progenitors initially differentiate as ZG cells and undergo lineage conversion to ZF as they move within the cortex. This relies on...

ea0037oc1.2 | Adrenal 1 | ECE2015

Functional study of ARMC5 (armadillo repeat containing 5), a new tumour suppressor gene involved in primary bilateral macronodular adrenal hyperplasia

Drougat ludivine , Espiard Stephanie , Doly Stephane , Rodriguez Stephanie , Rizk-Rabin Marthe , Libe Rossella , Assie Guillaume , Marullo Stefano , Ragazzon Bruno , Bertherat Jerome

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) are adrenocortical tumors leading to adrenal CushingÂ’s syndrome. Recently, our laboratory has identified the first gene predisposing frequently to PBMAH in adults, named ARMC5 (Armadillo Repeat Containing 5)1. The ARMC5-inactivating mutations identified in leucocyte and tumour DNA in PBMAH patients suggest that ARMC5 is a tumour suppressor gene. However, the mechanisms of action of ARMC5 remain unkno...