ea0081oc7.6 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022
Pellegata Natalia
, Minaskan Ninelia
, Gulde Sebastian
, Mohr Hermine
, Geppert Julia
, Rohm Maria
, Vitale Giovanni
, Gaudenzi Germano
, Dicitore Alessandra
, Franz Schilling
, Schillmaier Mathias
, Eisenhofer Graeme
, Herzig Stephan
, Roncaroli Federico
, Honegger Jurgen
Background: Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non-resectable neoplasms associated to frequent relapse and significant comorbidities. As current treatments often fail against NF-PitNETs, identifying actionable therapeutic targets is essential. We focused on the angiopoietin-2 (Angpt2)/Tie2 axis, usually active in endothelial cells (ECs).Methods: ANGPT2 plasma levels in NF-PitNET patients and healthy controls were m...