Endocrine Abstracts

Introduction: Metastatic well-differentiated rectal neuroendocrine neoplasms (NENs) are heterogeneous and considered ’immune-cold.’ Standard treatments include somatostatin analogues, peptide receptor radionuclide therapy and chemotherapy. We report a case where a patient responded to third-line immunotherapy, despite the absence of predictive biomarkers.Case Presentation: A 60-year-old man was referred for colonoscopy following bowel cancer sc...

Neuroendocrine tumours, although considered a rare neoplasia, have been increasing in incidence in developed countries over the last few decades. Previous research has identified several genetic components1. Despite this there is a gap in our knowledge of the causal mechanisms underlying the development of these tumours, with a low background mutation rate and lack of putative variants suggesting that other mechanisms are responsible. Recent work in Pancreatic Neuro...