Searchable abstracts of presentations at key conferences in endocrinology

ea0090p805 | Late-Breaking | ECE2023

Does the ‘obesity paradox’ have an expiration date? A bigdata retrospective cohort

Elkan Matan , Kofman Natalia , Minha Sa'ar , Rappoport Nadav , Zaidenstein Ronit , Koren Ronit

Background: Although obesity and overweight are associated with increased morbidity and mortality, higher body mass index (BMI) has been shown to be a protective factor from mortality in patients with acute infectious disease, also known as the ‘obesity paradox’. However, it is unknown whether these effects persist at long-term follow-up. Objective: To investigate the relationship between BMI and mortality after hospitalization with an infectio...

ea0070aep2 | Adrenal and Cardiovascular Endocrinology | ECE2020

Ovarian adrenal rest tumor in congenital adrenal hyperplasia: Is medical treatment the first line option?

Koren Ronit , Koren Shlomit , Khashper Alla , Benbassat Carlos , Pekar-Zlotin Marina , Vaknin Zvi

Introduction: Ovarian adrenal rest tumors (OARTs), in contrast with testicular adrenal rest tumors, are very rare. Up to date, 13 cases were reported in the literature; all treated surgically.Aim: We describe a case of a young female with uncontrolled classical congenital adrenal hyperplasia (CCAH), presenting with bilateral OARTs, successfully treated with steroid replacement.Methods: Data on clinical history and biochemical work-...

ea0081p461 | Thyroid | ECE2022

The effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with decompensated heart failure

Kagansky Dana , Or Karen , Elkan Matan , Koren Shlomit , Koren Ronit

Background: Hypothyroidism has profound effects on cardiac function, however, the effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with acute exacerbation of heart failure (HF) has not been evaluated yet.Methods: We conducted retrospective cohort analyses of outcomes among 231 consecutive patients with treated hypothyroidism who were admitted to the internal medicine departments of Shamir Medical Center with HF...

ea0056p463 | Diabetes complications | ECE2018

Influence of ethnicity on gestational diabetes mellitus in the center of Israel: a retrospective cohort study

Hochman Yuval , Wiener Yifat , Koren Shlomit , Koren Ronit

Aim: The aim of this study was to compare maternal and neonatal outcomes between Israeli Arab and Jewish women with GDM not controlled with lifestyle modification.Methods: We conducted a retrospective cohort study of women with GDM who were not controlled with lifestyle modification and were followed and gave birth in a university affiliated medical center between 2005 and 2015.Results: The study included 343 women, 45 (11.8%) of t...

ea0081p246 | Late-Breaking | ECE2022

Pituitary -adrenal axis insufficiency among hemodialysis patients

Bel-Ange Anat , Fux Daniel , Zelnik Yovel Dana , Koren Ronit , Beberashvili Ilia , Benbassat Carlos , Koren Shlomit

Background: The diagnosis of hypocortisolism is challenging in hemodialysis (HD) patients due to shared clinical features between renal failure and cortisol deficiency. We hypothesize that in a significant percentage of HD patients we miss cortisol deficiency.Methods: A prospective cohort of 56 end stage kidney disease patients on maintenance HD treatment (mean age 65.3±13.1, females 80 %) was studied. Low dose (1 mg) adrenocorticotropic hormone (AC...

ea0063gp124 | Diabetes: Late Complications | ECE2019

Unrecognized high risk for diabetic foot ulcer among hospitalized patients

Koren Shlomit , Sharabi Moriah , Levy Tamar Moriel , Fux Daniel , Koren Ronit , Rapoport Micha J

Aim: Loss of protective sensation (LOPS) commonly precede Diabetic foot ulcer (DFU) which is one of the most fearsome/serious diabetic complications and the leading cause of foot amputation in T2D patients. However, the prevalence of this high risk state is unknown.Methods: To estimate the presence of LOPS among hospitalized diabetes patients in internal wards, vibration perception and 10-g monofilament tests were done. Patients with foot ulcer or status...

ea0049ep1313 | Thyroid (non-cancer) | ECE2017

Management of relapsing Graves: a clinical survey among endocrinologists in Israel

Koren Shlomit , Shteinshnaider Miriam , Or Karen , Cantrell Dror , Benbassat Carlos A , Koren Ronit

Background: The management of relapsing Graves’ disease is controversial. Previous surveys from different regions in the world demonstrated variations in the clinical practices of patients with Graves’ disease relapse.Methods: To determine management pattern among endocrinologists in Israel an electronic questionnaire was e-mailed to all members of the Israeli Endocrine Society. Questionnaires included demographic data and clinical scenarios wi...

ea0041ep846 | Paediatric endocrinology | ECE2016

Pharmacokinetic and pharmacodynamic modeling of long acting human growth hormone (MOD-4023) in growth hormone deficient children

Fisher Dennis M. , Jaron-Mendelson Michal , Amitzi Leanne , Koren Ronit , Hart Gili

Introduction: OPKO Biologics has produced a long-acting human growth hormone (hGH), MOD-4023, containing three copies of a naturally-occurring peptide (C-terminal peptide, CTP) that markedly increases growth hormone’s in vivo residence. We describe the development and validation of a pharmacokinetic (PK) and pharmacodynamic (PD) model to characterize the relationship between MOD-4023 dose, serum concentrations (Cserum), and IGF-1 responses in healthy adults, GHD adults, a...

ea0070aep396 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Falling insulin requirements in women with pregestational diabetes

Carmi Adi , Wiener Yifat , Hovav Tali Shapiro , Koren Shlomit , Koren Ronit

Background: Previous studies evaluating the association between falling insulin requirements (FIR) during late pregnancy and adverse maternal and neonatal outcomes yielded controversial results.Methods: We conducted a retrospective cohort analysis of data collected from women delivering at Shamir Medical Center (a referral university-affiliated facility in central Israel), between 2008–2018. The percent of FIR was calculated by dividing the remaind...

ea0056p488 | Diabetes therapy | ECE2018

Short term adherence with discharge recommendation for insulin treatment among patients with type 2 diabetes

Koren Shlomit , Hemo Orel , Yoshpe Michael , Koren Ronit , Cantrell Dror , Rapoport Micha J.

Background: Basal-Bolus (BB) insulin treatment is increasingly used in uncontrolled diabetes patients during hospitalization and is commonly recommended on their discharge. However, the extent of adherence with this recommendation is unknown.Aim: To determine the short term adherence of type 2 diabetes mellitus (T2DM) patients discharged from internal medicine wards with recommendation for BB insulin treatment.Methods: Prescription...