Endocrine Abstracts

Introduction: Early detection of succinate dehydrogenase complex (SDH) mutations in patients with pheochromocytoma and paragaglioma (PPC/PGL) has important implications as it is associated with increased risk for malignancy. The use of negative immunohistochemical (IHC) staining for SDH subunit B, D, A (SDHB/-D/-A) has been proposed as an indicator of SDHs mutation and as an effective substitute for the high-cost genetic screening of all of these genes.M...

Background: Cancer of thyroid gland is rare in childhood, representing 1% of all pediatric malignancies. Primary thyroid lymphoma (PTL) is even rarer accounting for 5% of thyroid malignancies and 2% of extranodal lymphomas. The disease affects mainly adults in thesixth orseventh decade of life, with a female predominance. Most thyroid lymphomas are non-Hodgkin’s lymphomas (nHL) of B-cell origin. The most common type is Diffuse Large B- cell Lymphoma (DLBCL). Patients wit...

Introduction: IGF-1 overexpression has been associated with tumorigenesis. IGF-1Ea, IGF-1Eb and IGF-1Ec isoforms were shown to be regulated differently in cancer. IGF-1Ec and IGF-1Eb overexpression has been positively associated with cell survival and proliferation in various tumors. Elevated IGF1Eb/IGF-1Ea ratio has been suggested as a biomarker of cervical cancer prognosis. Herein, we aimed to examine the expression of IGF-1 isoforms in human adrenocortical carcinomas (ACCs)...