Searchable abstracts of presentations at key conferences in endocrinology

ea0094mte1.1 | Metabolism, Obesity and Diabetes | SFEBES2023

The "other" islet cells - state of the art for endocrinologists

Rorsman Patrik

The islets of Langerhans are the small endocrine micro-organs embedded in the exocrine pancreas. The beta-cells of the islets secrete insulin with its well-known blood glucose-lowering effects and that becomes deficient in diabetes. The islets also secrete glucagon (from alpha-cells), the body’s principal blood glucose-increasing hormone. The release of glucagon also becomes impaired in diabetes, which contributes to the metabolic impact of the lack of insulin and complic...

ea0038oc6.4 | Advances in reproduction and signalling | SFEBES2015

Calcium-sensing receptor internalisation is impaired in cells expressing FHH3-associated AP2σ mutations

Gorvin Caroline , Hastoy Benoit , Breitwieser Gerda , Rorsman Patrik , Thakker Rajesh

The calcium-sensing receptor (CaSR), a class C G-protein coupled receptor (GPCR) is critical for calcium homeostasis. The presence of CaSR at the plasma membrane (PM) is regulated by a balance between internalisation via clathrin-mediated endocytosis, and agonist-induced PM insertion from intracellular receptor pools, in a mechanism known as agonist-driven insertional signalling. Recently, mutations of the clathrin-mediated endocytic adaptor protein-2 sigma subunit, AP2σ,...

ea0015oc37 | Thyroid | SFEBES2008

Endocytosis involves a CLC-5 and KIF3B interaction: relevance to thyroid and renal tubular function

Reed Anita AC , Loh Nellie , Lippiat Jonathan , Partridge Chris , Galvanovskis Juris , Williams Sian , Jouret Francois , Wu Fiona , Courtoy Pierre , Nesbit M Andrew , Devuyst Olivier , Rorsman Patrik , Ashcroft Frances , Thakker Rajesh V

Endocrine cells utilise endocytosis to scavenge polypeptide hormones, and to generate signals from inactive precursors, such as release of thyroid hormones from thyroglobulin in thyrocytes, and activation of vitamin D after reabsorption of ultrafiltrated pro-vitamin D binding protein complex by renal proximal tubular cells (PTC). We have investigated the role of CLC-5, a chloride/proton antiporter expressed in apical endosomes and the apical plasma membrane of thyrocytes and P...