Searchable abstracts of presentations at key conferences in endocrinology

ea0032p104 | Bone and Osteoporosis | ECE2013

Vitamin D receptor, BsmI, FokI, ApaI, TaqI and estrogen receptor alpha, PvuII and XbaI, gene polymorphisms in women with osteoporosis

Vladoiu Susana , Oros Sabina , Manda Dana , Rosca Roxana , Ianas Olga

Objective: The aim of this study was to determine the frequencies of vitamin D receptor (VDR) Bsm1, Fok1, ApaI, TaqI and estrogen receptor α (ESR1) PvuII and XbaI polymorphisms in Romanian patients and to investigate their involvement in postmenopausal osteoporosis.Methods: The study was carried out on 82 postmenopausal women, aged over 60, divided into two groups: group 1-postmenopausal women with osteoporosis (34 subjects), group 2-postmenopausal ...

ea0014p536 | (1) | ECE2007

Age-related changes of circadian rhythmicity: relationship with melatonin.

Manda Dana , Ianas Olga , Vladoiu Suzana , Busu Carmina , Rosca Roxana

The suprachiasmatic nucleus (SCN) is the ‘master clock’ of the mammalian brain. It coordinates the peripheral clock in body, including the pineal clock that receives SCN input via a multisynaptic noradrenergic pathway. Melatonin is exclusively involved in signaling the ‘time of day’, ‘time of year’ to all tissues and is thus considered to be the chronological pacemaker or ‘zeitgeber’.Objective: To determine the chr...

ea0022p489 | Female reproduction | ECE2010

Polymorphisms in the estrogen receptor α gene and reproductive axis in women

Ianas Olga , Manda Dana , Savu Lorand , Vladoiu Suzana , Popa Oana , Rosca Roxana , Iordachescu Carmen

Background: ER-α gene (ESR1) polymorphisms have been associated with a variety of disorders including human infertility. In this study, we examined two polymorphisms of the estrogen receptor α (ESR1) gene, IVS-1 −397 T/C (dbSNP: rs2234693) and IVS-1 −351 A/G (dbSNP: rs9340799) in a sample of healthy women of reproductive age to determine whether are associated with hormonal levels for a better understanding of its biological actions in human development, ...

ea0022p674 | Obesity | ECE2010

Osteocalcin and the metabolic syndrome

Oros Sabina , Ianas Olga , Rosca Roxana , Vladoiu Suzana , Manda Dana , Dumitrache Constantin

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

ea0022p741 | Steroid metabolism &amp; action | ECE2010

Sex specific association between estrogen receptor alpha PvuII and XbaI gene polymorphisms and hormones

Vladoiu Susana , Ianas Olga , Manda Dana , Savu Lorand , Popa Oana , Rosca Roxana

Objective: To explore if the polymorphisms of the estrogen receptor alpha gene, XbaI (IVS1-351 A/G) and PvuII (IVS1-397 T/C) are associated with age-dependent changes in hormone levels for a better understanding of the biological actions of estrogens.Subjects and methods: Subjects, both genders aged between 20 and 80 years were classified into two groups: reproductive age (1) and over 55 years (2). The study received the Ethical Committee approval. Morni...

ea0020p670 | Steroid Receptors | ECE2009

Association study of the estrogen receptor alfa gene polymorphism and age-dependent endocrine changes in a Romanian population

Ianas Olga , Manda Dana , Savu Lorand , Vladoiu Susana , Popa Oana , Rosca Roxana , Joja Oltea , Covic Marcela

Objective: The aim of this study is the characterizing of genetic variation in PvuII and XbaI polymorphisms of the ESR1 gene associated with age-dependent endocrine, metabolic and cognitive changes in a representative sample of Romanian population stratified by age and sex.Subjects and methods: Subjects, both genders aged between 20 and 80 yr were assigned to three lots 1) 177 subjects aged 55–80 years with moderately cognitive impairment (MCI) (MMS...

ea0016p632 | Reproduction | ECE2008

Dynamic changes in the serum inhibin A and B levels correlated to reproductive hormones in women

Ianas Olga , Rosca Roxana , Vladoiu Suzana , Oros Sabina , Busu Carmina , Manda Dana , Dinu Dana , Jalba Pavel

To examine the hormonal characteristics related to age of reproductive axis, serum hormone profiles and inhibins A and B were investigated in fertile and menopausal women.Subjects: Forty-three cycling women (23–40-year-old) and 75 menopausal women (55–70-year-old) were studied. Serum 17-OHP, DHEA, DHEAS, androstendion, estradiol, estrone, progesterone, testosterone, free testosterone, DHT, SHBG, inhibin A and inhibin B, LH, FSH, Prl, TSH, GH, I...

ea0014p534 | (1) | ECE2007

Factors influencing the rhythmic secretion of melatonin in human

Rosca Roxana , Ianas Olga , Manda Dana , Vladoiu Suzana , Busu Carmina , Dinu Dana , Chioasca Carmen , Procopiuc Camelia

Objective: The present study examined the influence of light and dark, seasonal differences, electromagnetic fields, adrenergic and GABA-ergic control, age on melatonin secretion and also which factors affect rhythmicity of melatonin secretion, both in health and disease.Data were combined from a series of studies conducted between 1997 and 2006. Hormones were temporally assayed by immunometric assays.The results showed that melato...

ea0049ep1094 | Endocrine tumours and neoplasia | ECE2017

Study of CYP17 and PSA G158A polymorphisms in prostate cancer

Vladoiu Suzana , Manda Dana , Oros Sabina , Schipor Sorina , Preda Adrian , Gener Ismail , Picu Catalina , Rosca Roxana , Badiu Corin

The relationship between the level of genetic variation in CYP17, PSA genes and prostate cancer has been extensively studied but the results are still unclear. A 450c17a (CYP17) polymorphism A1/A2 was described to be significantly associated to prostate cancer. A SNP in the promotor PSA gene is an A to G substitution at position −158 (G158A) was proposed to interact differently with AR, thereby modifying the expression pattern and occurrence of prostate cancer.<p cla...

ea0049ep1176 | Male Reproduction | ECE2017

Methylation of the CPG islands from MTHFR promoter in male infertility

Vladoiu Suzana , Botezatu Anca , Dinu Draganescu Daniela , Manda Dana , Oros Sabina , Paun Diana , Rosca Roxana , Badiu Corin , Anton Gabriela

: A large number of studies are now focused on the causes of male infertility. Among these are epigenetic modifications, which are important contributors to reproductive pathology in the male by providing dynamic changes of the phenotype according to the environmental and metabolic factors. The most known epigenetic modification is DNA methylation and alterations in this pattern in several genes could induce male infertility. Alterations in DNA methylation patterns in several ...