Searchable abstracts of presentations at key conferences in endocrinology

ea0063p196 | Diabetes, Obesity and Metabolism 1 | ECE2019

Type 1 diabetic patients with more than five years of disease have increased global methylation levels

Duarte Guilherme CK , Assmann Tais S , Alves Melissa D , Rossoni Elis A , Correa Nathalia RF , Bauer Andrea C , Bossardi Ramon , Crispim Daisy

Background and aims: Type 1 diabetes mellitus (T1DM) results from a severe autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The triggering of autoimmunity against beta cells is caused by a complex interaction between environmental, genetic and epigenetic risk factors. Although significant progress has been made in elucidating the genetic factors associated with T1DM, the non-genetic components have remained poorly understood. ...