Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep441 | Thyroid | ECE2020

Management difficulties in nodular goiter associated with hypopharynx infiltration – case report

Teodoriu Laura , Magdalena Boboc Andreea , Neagu Georgiana , Ioan Bianca , Rosu Andreea , Christina Ungureanu Maria , Preda Cristina

Introduction: The connection between the pharynx and thyroid is close, so in the situations of concomitance: thyroid nodules and pharynx infiltration is very difficult to establish the primary lesion. Extralaryngeal spread of laryngopharyngeal cancer to the thyroid gland can occur by three pathways: direct extension, lymphatic spread or hematogenous spread. Of these three mechanisms, direct extension is the main mechanism because of the close anatomical relationship of the thy...

ea0081p141 | Pituitary and Neuroendocrinology | ECE2022

Bartter syndrome type I: a rare cause of polyuria-polydipsia syndrome with failure to thrive in a child

Barbacariu Ioana-Cristina , blesneac ilona-beatrice , Rosu Andreea , Protop Madalina , Munteanu Mihaela , Gorduza Eusebiu-Vlad , Preda Cristina

Introduction: Bartter syndrome (BS) is a rare autosomal recessive disorder, with an estimated prevalence of 1 in 1.000.000. It is characterized by a primary defect in sodium chloride reabsorption in the medullary thick ascending limb of Henle’s loop. Severe hypokalemia, metabolic alkalosis, hyponatremia, hypochloremia, hyperaldosteronism, and increased urinary loss of sodium, potassium, and chloride can raise the suspicion of BS, but genetic testing is required for a defi...

ea0063p498 | Calcium and Bone 2 | ECE2019

Bilateral femoral fractures in a pacient with primary hyperparathyroidism: A case report

Ioan Bianca , Ambarus Ioana , Feraru Laura , Chelaru Alina , Protop Madalina , Rosu Andreea , Neagu Georgiana , Grigorovici Alexandru , Ungureanu Cristina , Preda Cristina

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder often diagnosed in asymptomatic individuals on routine biochemical screening, which, if left untreated, can have devastating consequences. The main target organs of PTH are the skeletal system and the kidneys. Asymptomatic hypercalcaemia in young adults is uncommon, and patients who remain asymptomatic should be monitored for the development of complications that justify surgery.<p class="abste...

ea0070ep11 | Adrenal and Cardiovascular Endocrinology | ECE2020

A case of coexisting carotid body paraganglioma, adrenal incidentaloma and malignant peripheral nerve sheath tumor. Coincidence or something more?

Neagu Georgiana , Ungureanu Maria-Christina , Iftimie-Gavrilas Irina , Teodoriu Laura , Rosu Andreea , Chiriac Bianca , Protop Madalina , Chelaru Alina , Preda Cristina

Introduction: Paraganglioma (PGL) is a neuroendocrine tumor (NET) originating from the neural crest cells. Head and neck paraganglioma (HNPGL) often presents as an asymptomatic slow growing tumor and is rarely functional. Adrenal incidentaloma (AI) is defined as a silent adrenal mass detected on imaging performed for unrelated disorder. Malignant peripheral nerve sheath tumor (MPNST) is a variety of soft tissue sarcoma derived from cells of neural crest....

ea0070ep312 | Pituitary and Neuroendocrinology | ECE2020

Multiple endocrine neoplasia 1, 4 or simple concomitance ?

Chiriac Bianca , Christina Ungureanu Maria , Leustean Letitia , Rosu Andreea , Neagu Georgiana , Protop Madalina , Ambarus Ioana , Preda Cristina

Introduction: The association between pituitary adenoma and hyperparathyroidism is the main feature of multiple endocrine neoplasia (MEN) 1 but also for a novel MEN4 syndrome. Germline mutations in the cyclin-dependent kinase (CDK) inhibitor 1b gene (CDKN1B) were identified in patients with MEN4. The most common phenotype of the 19 established cases of MEN4 that have been described since now is primary hyperparathyroidism (PHPT) followed by pituitary adenomas. There are a limi...

ea0081ep589 | Endocrine-Related Cancer | ECE2022

Hyperandrogenism due to ovarian stromal hyperthecosis in a woman known with PCOS

Rosu Andreea , Ambăruş - Popovici Ioana , Chiriac Bianca , Blesneac Ilona - Beatrice , Proţop Mădălina , Patraşcu Ana-Maria , Scripcariu Viorel , Preda Cristina

Introduction: Ovarian hyperthecosis (OH) is a rare condition, reported only in case reports and small case series and is characterized by severe hyperandrogenism leading to virilisation and insulin resistance. The term hyperthecosis refers to the presence of luteinized thecal cells within a hyperplastic ovarian stroma and the pathophysiology of this remains poorly understood. Despite the fact that hyperandrogenism is a relatively common clinical problem, severe hyperandrogenis...

ea0063p835 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Bilateral adrenal masses in Addison’s disease: primary tumors or tuberculosis?

Protop Mădălina , Alexandra Ambărus Popovici Ioana , Bianca Ioan , Alina Chelaru , Andreea Rosu , Georgiana Neagu , Cătălina Bilha Stefana , Laura Feraru , Cristina Preda , Letitia Leustean

Introduction: Addison’s disease is a rare disorder, described mainly in isolated cases. The two most common cause of primary adrenal insufficiency are autoimmune adrenalitis and adrenal tuberculosis, which is still the primary cause of primary adrenal insufficiency (PAI) in developing countries. Adrenal tuberculosis is difficult to diagnose, the classic presentation with non specific symptoms delay the diagnosis. In some cases, the background of tuberculosis and hyperpigm...