Searchable abstracts of presentations at key conferences in endocrinology

ea0020p516 | Paediatric Endocrinology | ECE2009

Short stature in pediatric Cushing's syndrome: effectiveness of hypercortisolism cure

Paragliola Rosa Maria , Lovicu Rosa Maria , Ingraudo Francesca , Ianni Francesca , Locantore Pietro , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Cushing’s disease (CD) is the most common cause of endogenous Cushing’s syndrome in children and adolescents and represents a rare cause of short stature. A 14-year-old boy came to our attention for progressive weight gain and short stature. Birth length and weight were normal; clinical history was negative for use of glucocorticoids. At examination, height was 140 cm (3th centile), weight was 37.7 kg (10th centile). Tanner stage was: G2, PH 3, testis 3 ml. Hypothyro...

ea0016p150 | Clinical cases | ECE2008

Subclinical Cushing's syndrome (CS): role of 131I-iodomethylnorcholesterol scintigraphy in predicting the evolution of the disease

Paragliola Rosa Maria , Locantore Pietro , Ricciato Maria Pia , Rufini Vittoria , Perotti Germano , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Subclinical CS, mild hypercortisolism without overt clinical manifestations, is the most frequent (5–8%) hormonal abnormality detected in patients with secreting adrenal incidentalomas.Unclear clinical features and mild hypercortisolism make the diagnosis problematic, although laboratory criteria have recently been reviewed. In these cases, scintiscan is a central tool to define the adrenal functional activity.A 60-year-old ma...

ea0022p422 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Juvenile hypertension due to coexistence of two very rare etiologies

Paragliola Rosa Maria , Ianni Francesca , Ricciato Maria Pia , Rosa Annapina De , Gallo Francesca , Locantore Pietro , Senes Paola , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

The coexistence of pheochromocytoma and hyperreninemia secondary to renal artery stenosis, which both represent important causes of juvenile hypertension, has been reported in Literature, while association between pheochromocytoma and reninoma has never been described.We evaluated a 24-year-old boy, which came to our attention for severe hypertension, unresponsive to anti-hypertensive polytherapy. In 1996, because of elevated calcitonin levels (180 pg/ml...

ea0020p221 | Endocrine tumours and neoplasia | ECE2009

Severe elevation of testosterone serum levels as unique finding in occult Sertoli-Leydig ovarian cell tumors

Paragliola Rosa Maria , Ricciato Maria Pia , Gallo Francesca , De Rosa Annapina , Senes Paola , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Hirsutism affects 5–10% of women of reproductive age and may be the initial sign of an androgen disorder. We describe two cases of occult Sertoli-Leydig ovarian cell tumor suspected only on the basis of clinical and laboratory features.The first patient, a 42 year-old woman came to our attention for hirsutism. Several blood samples showed a very high testosterone concentration (~4 ng/ml), while non-ovarian causes of hyperandrogenism were excluded. A...

ea0016p793 | Thyroid | ECE2008

Hyperthyroidism associated to hyperthyrotropinemia: differential diagnosis between resistance to thyroid hormone and TSH secreting pituitary adenoma

Paragliola Rosa Maria , Locantore Pietro , Ingraudo Francesca , Gallo Francesca , Ianni Francesca , De Rosa Annapina , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Hyperthyroidism associated to hyperthyrotropinemia is a rare condition which can be due to two different causes: resistance to thyroid hormones and TSH secreting adenoma. The differential diagnosis is not easy.We have observed 8 patients with hyperthyroidism associated to inappropriately elevated TSH. All patients had similar basal levels of thyroid hormones and 7 out of 8 had a multinodular goiter.Four out of 8 patients showed lac...

ea0014p326 | (1) | ECE2007

Partial withdrawal of levothyroxine to stimulate serum thyroglobulin (TG) in the follow-up of differentiated thyroid carcinoma (DTC)

Ianni Francesca , Rota Carlo Antonio , Corsello Salvatore Maria , Rosa Annapina De , Gallo Francesca , Paragliola Rosa Maria , Ingraudo Francesca , Ricciato Maria Pia , Maussier Maria Ludovica , Salvatori Massimo , Pontecorvi Alfredo

Aim: We compared effectiveness of partial withdrawal of levothyroxine (L-T4) to the use of recombinant human TSH (rhTSH) in preparation for Tg testing. We also evaluated clinical aspects and quality-of-life (QOL) during both regimens.Materials and methods: Ten consecutive patients, previously treated with total thyroidectomy and radioiodine ablation for DTC, underwent rhTSH protocol and, after 15 days, reduced their L-T4 dose by 50% for 5 weeks. At the f...