Searchable abstracts of presentations at key conferences in endocrinology

ea0016p449 | Neuroendocrinology | ECE2008

Prevalence of metabolic syndrome in adult hypopituitaric patients with GH deficiency (GHD)

Di Somma Carolina , Rota Francesca , Tufano Antonella , Rota Francesca , Di Minno Dario Nicola , D'Andrea Marianna , Lombardi Gaetano

The prevalence of the metabolic syndrome is increasing worldwide. The untreated metabolic syndrome places individuals at risk both for diabetes and cardiovascular disease. Adult GH deficiency syndrome present some of the 5 features of the metabolic syndrome, abdominal obesity, high triglycerides, low HDL-cholesterol, elevations of blood glucose, hypertension and a 2-fold higher risk of death for CD compared with controls. The aim of this study was to determine the prevalence o...

ea0020p589 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Five year experience with GH replacement therapy on tumor occurrence or recurrence: one center study

Di Somma Carolina , Rota Francesca , Savanelli Maria Cristina , Lombardi Gaetano , Colao Annamaria

GH replacement is widely used in adults with hypopituitarism, but its effect on tumor occurrence and pituitary tumor recurrence is unknown. Furthermore, in literature there are scant with short follow-up time. The available data do not seem to suggest that rhGH replacement increased the incidence of regrowth of pituitary tumor and of cancer in adults with GHD, provided that IGF-1 concentrations remain within the normal range for age.The aim of our study ...

ea0014p594 | (1) | ECE2007

Cardiovascular risk and hypopituitarism: evaluation of the global cardiovascular absolute risk, using the individual score of the Progetto CUORE of the Istituto Superiore della Sanità

Di Somma Carolina , Cristina Savanelli Maria , Rota Francesca , Lombardi Gaetano , Colao Annamaria

Adults with hypopituitarism are known to have reduced life expectancy with a 2-fold higher risk of death for cardiovascular disease compared with controls. In Italy, to identify individuals at high risk for cardiovascular disease, the function of the Progetto CUORE has been identified and the global cardiovascular risk score has been built using data from different Italian cohorts. To assess the global cardiovascular risk score in adult hypopituitaric patients: 108 hypopituita...

ea0022p405 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Cinacalcet hydrochloride effectively controlled primary hyperparathyroidism in patients unresponsive to bisphosphonates

Faggiano Antongiulio , Somma Carolina Di , Milone Francesco , Ramundo Valeria , Rota Francesca , Vuolo Laura , Guerra Ermelinda , Colao Annamaria

Context: Until now the role of medical therapy in patients with primary hyperparathyroidism (PHP) was mainly based on the use of bisphosphonates. Recently, cinacalcet hydrochloride was reported to be effective in control hypercalcemia in PHP. The aim of this study was to evaluate the efficacy of cinacalcet in PHP patients who were not effectively controlled with alendronate.Patients and methods: Fourteen PHP patients (mean age 64.1±2.6) were include...

ea0016p394 | Neuroendocrinology | ECE2008

Growth hormone (GH) treatment on atherosclerosis: results of a 5 years open, prospective, controlled study in male patients with severe GH deficiency

Colao Annamaria , Di Somma Carolina , Spiezia Stefano , Savastano Silvia , Rota Francesca , Savanelli Maria Cristina , D'Andrea Marianna , Lombardi Gaetano

Background: Severe GH deficiency (GHD) is associated with, increased cardiovascular (CV) risk and intima-media thickness (IMT) at major arteries.Objective: To investigate the long-term (5-years) effects of GH replacement on insulin resistance (IR) syndrome (IRS) (at least two of: triglycerides levels ≥1.7 mmol/l, HDL-cholesterol levels ≤1.0 mmol/l, blood pressure above 130/85 mmHg, fasting glucose 6.1–7 or 2 h after glucose 7.7–11.1...

ea0016p373 | Growth factors | ECE2008

Low insulin-like growth factor (IGF) I, IGF binding protein-3 and acid labile subunit (ALS) levels in young ischemic stroke: a prospective case-control study

Di Somma Carolina , Savanelli Maria Cristina , Tufano Antonella , Rota Francesca , Di Minno Dario Nicola , D'Andrea Marianna , Lombardi Gaetano , Minno Giovanni Di , Colao Annamaria

Animal and observational studies suggest that the IGF axis is involved in the pathogenesis of ischemic stroke; moreover, endogenous IGF-I could influence the evolution of ischemic stroke in humans and thereby contribute to an improved clinical and functional outcome. To assess and correlate the IGF-I axis with biochemical parameters in young patients experiencing ischemic stroke (32 aged 15–45 years,19F, BMI: 25.5±3.4 kg/m2), we evaluated IGF-I, IGFBP-3, A...

ea0014p262 | (1) | ECE2007

Body composition and GH status in morbidly obese females before and after laparoscopic silicone adjustable-gastric banding

Savastano Silvia , Colao Annamaria , Rota Francesca , Vuolo Laura , Cristina Savanelli Maria , Cascella Teresa , Orio Francesco , Angrisani Luigi , Lombardi Gaetano , Di Somma Carolina

The GH/IGF-I axis function are reported to ameliorate after weight-loss. Bariatric surgery leads to a significant weight loss in morbidly obese patients. We investigated the relationships between GH/IGF-I axis and body composition in 20 morbidly obese females (BMI: 44.8±4.7; waist circumference (W) 119.5±7.2 cm, age 33.7±11.7 yrs) with a normal glucose tolerance, before and after laparoscopic silicone adjustable-gastric banding (LASGB). The GH axis was evaluated...

ea0014p326 | (1) | ECE2007

Partial withdrawal of levothyroxine to stimulate serum thyroglobulin (TG) in the follow-up of differentiated thyroid carcinoma (DTC)

Ianni Francesca , Rota Carlo Antonio , Corsello Salvatore Maria , Rosa Annapina De , Gallo Francesca , Paragliola Rosa Maria , Ingraudo Francesca , Ricciato Maria Pia , Maussier Maria Ludovica , Salvatori Massimo , Pontecorvi Alfredo

Aim: We compared effectiveness of partial withdrawal of levothyroxine (L-T4) to the use of recombinant human TSH (rhTSH) in preparation for Tg testing. We also evaluated clinical aspects and quality-of-life (QOL) during both regimens.Materials and methods: Ten consecutive patients, previously treated with total thyroidectomy and radioiodine ablation for DTC, underwent rhTSH protocol and, after 15 days, reduced their L-T4 dose by 50% for 5 weeks. At the f...

ea0014p595 | (1) | ECE2007

Traumatic brain injury (TBI) and lipid profile abnormalities: study 12 months after the brain injury

Di Somma Carolina , Rota Francesca , Rovere Silvia , Rosaria Ambrosio Maria , Fusco Alessandra , Corneli Ginevra , Bianchi Antonio , De Marinis Laura , degli Uberti Ettore Ciro , Lombardi Gaetano , Ghigo Ezio , Colao Annamaria , Aimaretti Gianluca

Aim of this study was to evaluate lipid profile and the severity of GHD, in a large group of TBI patients with or without GH deficiency. We assayed lipid profile (Total-, HDL- Cholesterol, Triglycerides) in 62 TBI subjects 12 months after TBI (41 M, 21 F, 13–81 yrs, BMI: 24.6±0.6 kg/m2), and in 62 sex-, age- and BMI-matched controls. Based on the GH peak after GHRH+ARG test, patients were stratified as: 1) severe GHD (GH peak ≤ 9 μg/l; <i...