Endocrine Abstracts

Introduction: ACTH-secreting pituitary adenomas occasionally present as aggressive pituitary tumors (APT), with invasion of surrounding structures, rapid growth, resistance to conventional therapies and multiple recurrences. In rare cases they can progress to pituitary carcinomas (PC) in several years, diagnosis being made upon the documentation of systemic or central nervous system (CNS) metastatic spread. Among pituitary carcinomas, the most common malignant subtypes are lac...

Background: Prolactinoma is the most frequent pituitary tumour. However, peculiar aspects may induce difficulties in their evolution and management. Malignant prolactinoma is exceptionally rare and it cannot be diagnosed on histological grounds alone. We report the case of a recurrent, possibly malignant macroprolactinoma.Case report: 46 years old female, addressed for bitemporal hemianopia, without other clinical signs. MRI confirmed a pituitary macroad...

Introduction: The coexistence of pituitary adenoma and meningiomas is very rare. It is debatable if meningiomas result as a consequence of hormone dependent growth or secondary to radiation.We report a rare case of coexisting brain tumors: a prolactin secreting pituitary adenoma and two meningiomas in a 54-year-old female patient.Case report: Onset at 46 years with bitemporal hemianopsia, without other clinical complaints. MRI conf...

Introduction: Plurihormonal pituitary adenomas are unusual tumors which typically belong to one cell lineage and have an incidence of approximately 1.3%, the most common combination being GH, PRL and glycoprotein hormone subunits. There are a few cases in the literature describing cosecretion of GH and ACTH from a pituitary adenoma, the incriminated pathogenesis being the origin from different cell lineages and the aberrant patterns of transcription factors.<p class="abste...

Introduction: Central hyperthermia is frequent in patients with brain injury and is characterized by a rapid onset with high temperatures, marked temperature fluctuations and poor response to antipyretics. It is associated with worse outcomes in the injured brain, thus it is important to aggressively manage it.Case-report: We report a case of a 9-year-old boy diagnosed with sellar and suprasellar adamantimomatous craniopharyngioma at the age of 5 when he...

Introduction: Inappropriate secretion of TSH, despite elevated levels of T4, is due to either a TSH-secreting adenoma (TSHoma) or thyroid hormone resistance (RTH). RTH is a rare disorder, usually caused by mutations in the thyroid hormone receptor beta, characterized by a variable tissue hyporesponsiveness to thyroid hormone. The increased level of TSH may predispose to thyrotroph hyperplasia and possible adenoma formation.Case report: A 21 years old fem...

Introduction: Prolactinomas, prevalent among young women, are the most frequently encountered secreting pituitary tumors. Pituitary apoplexy is a rare and severe complication of prolactinomas, which manifests with rapid onset symptoms like severe headaches, visual disturbances, hormonal imbalances, requiring urgent medical care.Case report: We report the case of a 46-year-old female patient with history of type 2 diabetes, early menopause (30 years old, ...

Multiple pituitary hormone deficiency (MPHD) associates variable misleading hypothalamic-pituitary imaging (MRI) aspects, with unpredictable dynamics until puberty, which requires a differential diagnosis with acquired pituitary changes that can modify subsequent case management. The patient, aged 7 years and 4 months, with no significant personal or hereditary antecedents, presented at the age of 5 years and 7 months to the Iasi Endocrinology Clinic for severe short stature (...