Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep712 | Pituitary and Neuroendocrinology | ECE2022

Evolution from recurrent cushing’s disease to pituitary carcinoma

Anisia Miruna , Dumitru Teodora , Stoica Alexandra , Ungureanu Maria Christina , Preda Cristina , Rotariu Daniel , Leustean Letitia

Introduction: ACTH-secreting pituitary adenomas occasionally present as aggressive pituitary tumors (APT), with invasion of surrounding structures, rapid growth, resistance to conventional therapies and multiple recurrences. In rare cases they can progress to pituitary carcinomas (PC) in several years, diagnosis being made upon the documentation of systemic or central nervous system (CNS) metastatic spread. Among pituitary carcinomas, the most common malignant subtypes are lac...

ea0049ep1073 | Pituitary - Clinical | ECE2017

Aggressive macroprolactinoma – exception to the rule

Belceanu Alina Daniela , Constantinescu Georgiana , Crumpei Iulia , Bursuc Anamaria , Rotariu Daniel , Constantinescu Aurora , Ciubotaru Vasile , Preda Cristina , Vulpoi Carmen

Background: Prolactinoma is the most frequent pituitary tumour. However, peculiar aspects may induce difficulties in their evolution and management. Malignant prolactinoma is exceptionally rare and it cannot be diagnosed on histological grounds alone. We report the case of a recurrent, possibly malignant macroprolactinoma.Case report: 46 years old female, addressed for bitemporal hemianopia, without other clinical signs. MRI confirmed a pituitary macroad...

ea0041ep304 | Clinical case reports - Pituitary/Adrenal | ECE2016

Association of two aggressive tumors (prolactinoma and multiple meningioma) – difficult issue, difficult management

Constantinescu Georgiana , Belceanu Alina , Haba Danisia , Constantinescu Aurora , Rotariu Daniel , Bursuc Anamaria , Armasu Ioana , Preda Cristina , Vulpoi Carmen

Introduction: The coexistence of pituitary adenoma and meningiomas is very rare. It is debatable if meningiomas result as a consequence of hormone dependent growth or secondary to radiation.We report a rare case of coexisting brain tumors: a prolactin secreting pituitary adenoma and two meningiomas in a 54-year-old female patient.Case report: Onset at 46 years with bitemporal hemianopsia, without other clinical complaints. MRI conf...

ea0056p699 | Clinical case reports - Pituitary/Adrenal | ECE2018

Acromegaly and subclinical Cushing’s disease: a rare case of a pituitary macroadenoma secreting both GH and ACTH

Teusan Teodora , Ciobotar Mihaela , Ungureanu Maria-Christina , Preda Cristina , Florescu Alexandru , Mogos Voichita , Rotariu Daniel , Leustean Letitia

Introduction: Plurihormonal pituitary adenomas are unusual tumors which typically belong to one cell lineage and have an incidence of approximately 1.3%, the most common combination being GH, PRL and glycoprotein hormone subunits. There are a few cases in the literature describing cosecretion of GH and ACTH from a pituitary adenoma, the incriminated pathogenesis being the origin from different cell lineages and the aberrant patterns of transcription factors.<p class="abste...

ea0056p708 | Clinical case reports - Pituitary/Adrenal | ECE2018

Bromocriptine for management of a patient with cranipharyngioma and central hyperthermia after neurosurgery: a case report

Tudurean-Olteanu Anca-Georgiana , Hrisca Anamaria , Nechita Mirela Claudia , Rotariu Daniel , Preda Cristina , Leustean Letitia , Ungureanu Maria Christina

Introduction: Central hyperthermia is frequent in patients with brain injury and is characterized by a rapid onset with high temperatures, marked temperature fluctuations and poor response to antipyretics. It is associated with worse outcomes in the injured brain, thus it is important to aggressively manage it.Case-report: We report a case of a 9-year-old boy diagnosed with sellar and suprasellar adamantimomatous craniopharyngioma at the age of 5 when he...

ea0056p1000 | Clinical case reports - Thyroid/Others | ECE2018

Thyroid hormone resistance and pituitary macroadenoma: is there a connection? – case report

Hrisca Anamaria , Tudurean Olteanu Georgiana , Nechita Mirela , Bilha Stefana , Rotariu Daniel , Leustean Letitia , Preda Cristina , Christina Ungureanu Maria

Introduction: Inappropriate secretion of TSH, despite elevated levels of T4, is due to either a TSH-secreting adenoma (TSHoma) or thyroid hormone resistance (RTH). RTH is a rare disorder, usually caused by mutations in the thyroid hormone receptor beta, characterized by a variable tissue hyporesponsiveness to thyroid hormone. The increased level of TSH may predispose to thyrotroph hyperplasia and possible adenoma formation.Case report: A 21 years old fem...