Endocrine Abstracts

Sarcoïdosis is a relatively frequent systemic disease of unknown origin. Prevalence is about 4.7–64 in 100 000. We report the case of a 53-year-old woman followed in our institution since 2007 for a thyroid carcinoma. In 2010, she was diagnosed refractory thyroid carcinoma because of a high thyroglobulin assay (477 μg/l) without uptake on post-therapeutic (131I) whole body scan. Thereafter, the story is marked by the appearance in 2011 of multiple cer...

Objective: Immune checkpoint inhibitors (ICI) are used for treatment of non-small cell lung cancer (NSCLC) and are associated with immune-related adverse events (irAEs), especially thyroid dysfunction. Few studies found an association between thyroid dysfunction and response to Nivolumab in the NSCLC The objective of this retrospective cohort study was to investigate the association between the occurrence of thyroid dysfunction in patients treated with Nivolumab for a NSCLC an...

Development in autologous bone marrrow transplantation (auto-BMT) has improved survival, but new endocrine complications now emerge. If primary thyroid and gonadal deficiencies are documented in medical literature, pituitary deficiencies are less well-known, especially in adults. The aim of the study was to investigate pituitary function in patients who survived at least one year after transplantation for malignant haematologic disorders by a prospective study.<p class="ab...

Background: Radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) patients with distant metastases show poor survival rates. However, patients’ outcome can be very heterogeneous, with cases spanning from microscopic slowly growing metastases to symptomatic, rapidly progressive disease. The aim of this study was to assess the overall survival (OS) of RAI-R DTC patients with distant metastases and to identify the prognostic factors associated with OS.<p class...

Introduction: Whether F18-choline PET/CT (FCH PET/CT) should replace Tc99m-sestaMIBI SPECT/CT (MIBI SPECT/CT) as a first-line imaging technique for preoperative localisation of parathyroid adenomas in primary hyperparathyroidism (pHPT) is unclear.Methods: We conducted a multicentre randomized open diagnostic intervention phase III trial in adults with primary hyperparathyroidism and indication for surgical treatment. Patients were assigned in a 1:1 ratio...

Introduction: Vandetanib was the first tyrosine kinase inhibitor approved for the first line systemic treatment of progressive metastatic or locally advanced medullary thyroid carcinomas (MTC). Previous studies reported median duration of treatment (DOT) around 20 months with a subset of patients presenting long-term responses. Little is known on the impact of RET mutation status on the response duration.Objectives: To evaluate the proportion and compare...