Searchable abstracts of presentations at key conferences in endocrinology

ea0038oc4.6 | Diabetes and cardiometabolic complications | SFEBES2015

Cardiac fibrosis and the balance between glucocorticoid and mineralocorticoid receptors signalling

Richardson Rachel , Batchen Emma , Darroch Rowan , Scullion Kathleen , Rog-Zielinska Ewa , Kenyon Christopher , Gray Gillian , Chapman Karen

Specific variations in the human glucocorticoid receptor (GR) gene associate with increased cardiovascular disease risk. GR signalling is essential for cardiac maturation in utero and adult mice with cardiomyocyte and vascular smooth muscle deletion of GR (SMGRKO mice) have cardiac hypertrophy, fibrosis and impaired function. Intriguingly, levels of left ventricle (LV) mRNA encoding the mineralocorticoid receptor (MR), which is pro-fibrotic in heart, rise postnatally ...