Searchable abstracts of presentations at key conferences in endocrinology

ea0032p169 | Calcium and Vitamin D metabolism | ECE2013

Impact of vitamin deficiency and oF GH–IGF1 on cardiovascular risk in hypopituitaric patients

Savanelli Maria Cristina , Scarano Elisabetta , Vuolo Laura , Brunelli Vincenzo , Rubino Manila , Colao Annamaria , Di Somma Carolina

To determine a correlation between Vitamin D, GH, IGF1 and cardiovascular risk we enrolled. 41 GHD patients (22 M, 19 F, age 18–84 years) and 41 controls. In all we determined: anthropometric parameters, blood pressure (BP), lipid and glucose profile, PTH, 25-OH-vitamin D, GH peak after GHRH+ARG, IGF1. Metabolic syndrome (MS) was evaluated by the IDF criteria.The vitamin D were lower in patients than in controls (21.3±12.3 vs 28.2±9.4, <em...

ea0041gp230 | Thyroid Cancer (1) | ECE2016

Analysis of germline VEGF-A SNPs allows the identification of a subgroup of ATA low-intermediate risk DTC (differentiated thyroid cancer) patients with poor probability to develop recurrences

Marotta Vincenzo , Sciammarella Concetta , Capasso Mario , Testori Alessandro , Gambardella Claudio , Grasso Marica , Rubino Manila , De Palma Maurizio , Grazia Chiofalo Maria , Pivonello Claudia , Pivonello Rosario , Santini Luigi , Pezzullo Luciano , Colao Annamaria , Faggiano Antongiulio

Introduction: Constitution of new blood vessels is crucial for cancer self-maintenance and progression. Neo-angiogenesis may be affected from hereditary traits, namely the presence of SNPs (single nucleotide polymorphisms) of genes involved in its regulation. VEGF-A represents the main regulator of angiogenesis. Germline SNPs of the VEGF-A gene have been associated to outcome of several cancers, but no data exist about differentiated thyroid cancer (DTC).<p class="abstext"...

ea0035p128 | Calcium and Vitamin D metabolism | ECE2014

Cinacalcet hydrochloride more efficiently controls serum calcium levels in mild-asymptomatic primary hyperparathyroidism without surgery criteria, as compared with surgical cases

Marotta Vincenzo , di Somma Carolina , Rubino Manila , del Prete Michela , Marciello Francesca , Ramundo Valeria , Sciammarella Concetta , Buonomano Pasqualina , Carratu Annachiara , de Luca di Roseto Chiara , Colao Annamaria , Faggiano Antongiulio

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...