ea0014p532 | (1) | ECE2007
Bergamaschi Silvia
, Giavoli Claudia
, Ferrante Emanuele
, Rusconi Roberto
, Lania Andrea G
, Spada Anna
, Beck-Peccoz Paolo
Cortisol and cortisone are interconverted by type 1 and type 2 11ßhydroxysteroid dehydrogenase (11ßHSD) isoenzymes. The type 1 isoenzyme is a widely expressed reductase that converts cortisone to cortisol regulating glucocorticoid tissue exposure. Its activity is inhibited by GH and IGF-I, being increased in GH deficiency (GHD) and decreased in acromegaly. In our experience rhGH therapy unmasked a central hypoadrenal state in adults with organic GHD, likely by normal...