Endocrine Abstracts

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All of the new drugs that have been used or become available over the past decade for the prevention and treatment of osteoporosis are so-called “anti-resorptives”. These include bisphosphonates (etidronate, alendronate and risedronate), hormone replacement therapy, selective estrogen receptor modulators (raloxifene), and calcitonins. All reduce vertebral fracture risk and some reduce nonvertebral fracture risk, but there are obvious theoretical advantages to using...

IntroductionThe secretion of multiple hormones occurs in both a circadian and an ultradian manner. Both animal and human studies have shown that cortisol has an ultradian rhythm. Variations in ultradian cortisol secretion may explain inter-individual variation in the stress response.ObjectiveWe have developed an automated blood sampling system (ABS) that allows undisturbed sampling of blood, thus reducing str...

Background: Patients with small bowel neuroendocrine tumors (SBNETs) frequently present with metastatic disease, and unfortunately, the range and efficacy of available therapies is limited. Immunotherapeutic checkpoint inhibitors have demonstrated benefit in other malignancies and may also play a role in SBNETs, although relatively little is known about the immune infiltrate in these tumors. Toward a goal of developing novel immunomodulatory strategies, we sought to evaluate t...