ea0032oc3.5 | Thyroid | ECE2013
Russo Eleonora
, Salzano Marcella
, De Falco Valentina
, Santoro Massimo
, Mian Caterina
, Barollo Susi
, Vitale Mario
Recent studies demonstrated that the calcium/calmodulin dependent kinase 2 (CaMKII) is involved in the regulation of proliferation and survival of epithelial cells, were it phosphorylates RAF-1 and modulates MAPK pathway. A endogenous CaMKII inhibitor (hCaKIINα) is expressed in some cell types. It is down-expressed in colon and in ovarian cancer where it inversely correlates with the disease extension.Aim of our study is to determine the possible ro...