Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1132 | Thyroid Cancer | ECE2014

Treatment outcomes and prognosis of medullary thyroid carcinoma in a tertiary endocrinology center

Dobrescu Ruxandra , Stanescu Bogdan , Badiu Corin

A rare and aggressive form of thyroid malignancy, medullary thyroid carcinoma (MTC) is virtually incurable except by complete surgical resection. Due to its insidious onset and extensive spread at diagnosis, its prognosis is often poor.Aim: To evaluate treatment outcome and prognosis in patients diagnosed with MTC admitted to our department between 2004 and 2013.Patients and methods: We identified 21 patients (eight men and 13 wome...

ea0025p249 | Pituitary | SFEBES2011

Prospective assessment of pituitary function in patients with macroprolactinoma treated with cabergoline

Karavitaki Niki , Dobrescu Ruxandra , Wass John

Background: Patients with macroprolactinoma often present with pituitary hormone deficits associated with hyperprolactinaemia or mass effect. Restoration of normoprolactinaemia and tumour shrinkage by dopamine agonist is expected to reverse, at least partially, the pituitary dysfunction. Studies assessing prospectively the pituitary function in subjects with macroprolactinoma treated with cabergoline are lacking.Aim: To check the time course of recovery ...

ea0081ep1082 | Thyroid | ECE2022

Lipid profile during block replace treatment in Graves disease

Stancu Ana-Maria , Dobrescu Ruxandra , Semonia Stanescu Laura , Badiu Corin

Introduction: Graves’ disease (GD) is an autoimmune disorder causing hyperthyroidism. Variations of functional profile as well as type and titer of thyroid specific antibodies makes the control often difficult. One treatment option is adding levothyroxine to anti-thyroid drugs (ATDs), so-called block-replace therapy (BRT).Aim: To study the BRT impact on lipid profile, thyroid function tests (TFTs) and TSH receptor antibodies (TRAb). <p class="ab...

ea0063p798 | Thyroid 2 | ECE2019

Value and limitation of serum MMP-9 in thyroid nodular disease

Dobrescu Ruxandra , Picu Catalina , Manda Dana , Caragheorgheopol Andra , Badiu Corin

Background: Matrix metalloproteinase-9 (MMP-9) is overexpressed in almost all human cancers (including thyroid). High serum levels are generally associated with an adverse prognosis, although the evidence related to thyroid cancer is still controversial.Aim: We aimed to evaluate pre- and post-surgical serum MMP-9 levels for its diagnostic and prognostic value in a series of patients with benign thyroid disease (BD) or differentiated thyroid carcinoma (DT...

ea0038p452 | Thyroid | SFEBES2015

Diagnostic and therapeutic challenges in medullary thyroid carcinoma

Dobrescu Ruxandra , Baciu Ionela , Ioachim Dumitru , Badiu Corin

Medullary thyroid carcinoma (MTC) is an aggressive form of malignancy, virtually incurable except by complete surgical resection. With insidious onset and occasional rare clinical variants, it is often diagnosed late in the course of disease and has a poor prognosis. We aimed to evaluate diagnostic efficiency, treatment modalities and outcome in patients admitted to our department between 2004 and 2015, diagnosed with MTC, with emphasis on rare clinical presentations. We ident...

ea0037ep814 | Pituitary: clinical | ECE2015

Cabergoline test as a predictor for long term therapy management of hyperprolactinaemia

Caragheorgheopol Andra , Busila Iuliana , Dobrescu Ruxandra , Gogoi Adriana , Badiu Corin

Objective: To determine if the response to one single dose of 0.5 mg cabergoline (CAB) can be used as predictor for choosing personalized therapy of hyperprolactinaemia. Although CAB is a selective, long half-life D2-receptor agonist some patients proved to be resistant with minimum to no response in serum prolactin and tumour shrinkage, even after a few months of treatment.Patients and methods: A dose of 0.5 mg CAB was administered orally to a number of...

ea0037ep1305 | Clinical Cases–Thyroid/Other | ECE2015

Virilisation due to a Leydig cell tumour of the ovary: diagnostic and therapeutic challenges

Dobrescu Ruxandra , Poalelungi Cristian , Ceausu Iuliana , Hortopan Dan , Badiu Corin

Introduction: Severe hirsutism and virilisation, especially if occurring later in life and with rapid onset, should prompt the search for rare but potentially threatening causes such as an androgen secreting ovarian or adrenal tumour.We present the case of a 47-year-old woman referred to our clinic with obesity, severe hirsutism, alopecia, acne, and deepening of the voice that appeared insidiously 2 years ago, along with amenorrhoea which she interpreted...

ea0034p426 | Thyroid | SFEBES2014

Small papillary thyroid carcinoma: a ‘benign’ condition?

Dobrescu Ruxandra , Ioachim Dumitru , Simioniuc Anca , Badiu Corin , Goldstein Andrei

Often discovered incidentally, small foci (≤2 cm) of papillary thyroid carcinomas (PTC) are its most frequent presentation. Despite favourable prognosis, the extent of surgery and use of radioablation is still controversial.Objective: Prospective cohort study of all patients admitted between 2007 and 2011, for thyroid surgery in the Institute of Endocrinology, Bucharest, Romania, and had pT1a or pT1b PTC.Patients and methods:...

ea0032p184 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Adults with GH deficiency have subclinical longitudinal left ventricular dysfunction, without significant vascular function impairment, suggesting intrinsic myocardial disease

Badiu Corin , Mihaila Sorina , Mincu Raluca , Dobrescu Ruxandra , Vinereanu Dragos

Aims: GH deficiency (GHD) is associated with increased cardiovascular events. We aimed to evaluate cardiac, arterial, and endothelial function, by conventional and 2D speckle tracking echocardiography (STE), and biomarkers (proBNP and troponin I), in GHD patients by comparison with normal individuals with similar cardiovascular risk profile.The study included 52 GHD patients (46.9±15.6, 36 males), free of cardiovascular disease, severe hypertension ...

ea0032p1094 | Thyroid cancer | ECE2013

Medullary thyroid carcinoma – a narrow surgical window

Dobrescu Ruxandra , Iacob Diana , Stanescu Bogdan , Badiu Corin

Introduction: Occurring sporadically or as part of a familial syndrome, medullary thyroid carcinoma (MTC) is insidious in onset, aggressive in behavior and invariably a challenge to the clinician and surgeon.Objective: To define the relationship between biochemical parameters, disease progression, and treatment outcome in patients with MTC.Patient and methods: We studied 35 patients (11 men, 24 women) aged 50.9±14.8 years, adm...