Searchable abstracts of presentations at key conferences in endocrinology

ea0029p280 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

The role of testosterone activation of liver X receptor in a human macrophage cell line and its implications for the treatment of type 2 diabetes and atherosclerosis

Kilby E. , Akhtar S. , Jones T.

Testosterone deficiency is common in men with type 2 diabetes (T2D) and cardiovascular diseases (CVD), such as atherosclerosis. Previous studies have shown that testosterone replacement improves several cardiovascular risk factors including insulin resistance, glycaemic control, cholesterol and inflammation. The mechanisms by which testosterone mediates these effects are unknown. LXR, a nuclear receptor also regulates these cardiovascular risk factors and the atheroprotective ...

ea0029p961 | Female Reproduction | ICEECE2012

Plasma adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a case–control study

Singh S. , Akhtar N. , Ahmad J.

Objective: An interaction between adiponectin, steroid synthesis or action and measures of insulin resistance (IR) have been reported in the pathogenesis of polycystic ovary syndrome (PCOS). The present study was done to determine plasma adiponectin concentration (PAC) in women with and without PCOS and to assess its correlation to the hormonal and metabolic parameters including measures of IR. The effect of metformin for 6 months in PCOS was also evaluated.<p class="abste...

ea0013p61 | Clinical practice/governance and case reports | SFEBES2007

A 57 year old lady bilateral adrenal mass and adrenal insufficiency

Akhtar S , Dunne P , Mishra B

We report a case of a 57 year old lady who presented with marked weight loss, dizziness and general malaise. The physical examination revealed pallor, hypotension, tachycardia and dehydration. There was no muco-cutaneous pigmentation. Routine biochemistry showed normocytic anaemia, hyponatraemia, mild hyperkalaemia and renal impairment. Abdominal ultrasound showed presence of bilateral large supra-renal masses. A short synacthen test showed sub-optimal rise in plasma cortisol ...

ea0029p269 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Testosterone replacement therapy inhibits key enzymes of fatty acid synthesis in mouse liver

Brooke J. , Kelly D. , Akhtar S. , Muraleedharan V. , Jones T.

Fatty liver (Hepatic Steatosis) is common in men with type 2 diabetes mellitus (T2DM). Furthermore there is a high prevalence of testosterone deficiency (up to 40%) in this population. Testosterone replacement therapy (TRT) has been shown to reduce elevated serum liver transaminase levels in hypogonadal men. The testicular feminised (Tfm) mouse exhibits a non-functional androgen receptor (AR) and low circulating testosterone levels. We have previously shown that a high-fat die...

ea0029p270 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of testosterone on hepatic liver X receptor and ApoE expression as a potential mechanism of atheroprotection in the testicular feminised mouse

Kelly D. , Akhtar S. , Brooke J. , Channer K. , Jones T.

Testosterone deficiency is associated with several cardiovascular risk factors. Testosterone replacement therapy (TRT) improves insulin sensitivity, inflammation and cholesterol. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism, stimulates cholesterol efflux and ApoE, and suppresses inflammation. LXR agonists cause hepatic steatosis but protect against atherosclerosis. TRT attenuates high-cholesterol diet-induced hepatic steatosis in th...

ea0029p559 | Diabetes | ICEECE2012

Low testosterone is associated with decreased expression of glut-4 and hexokinase 2 in muscle of the testicular feminised mouse

McLaren D , Kelly D , Akhtar S , Channer K , Jones T

Testosterone deficiency is a common in men with type two diabetes (T2D). We have shown testosterone replacement therapy (TRT) improves insulin resistance and glycaemic control. The mechanisms by which testosterone mediates this action are unknown but may be due to a combination of effects on muscle, liver and adipose tissues. This study investigates the expression of Glut4 and HK2, (two key proteins involved in insulin sensitivity) in muscle tissue of the testicular feminised ...

ea0019p369 | Thyroid | SFEBES2009

Epitopes for calcium-sensing receptor antibodies in patients with autoimmune polyendocrine syndrome type 1 are located in the N-terminal of the extracellular domain

Kemp EH , Gavalas NG , Akhtar S , Krohn KJE , Brown EM , Watson P , Weetman AP

Context: Autoimmune polyendocrine syndrome type 1 (APS1) is an autosomal recessive disorder caused by mutations in the autoimmune regulator gene. Hypoparathyroidism occurs in 80% of patients with APS1 and has been suggested to result from an autoimmune reaction against the calcium-sensing receptor (CaSR) on parathyroid cells. Previously, we have detected CaSR-binding antibodies in patients with APS1 using immunoprecipitation and flow cytometry assays.Obj...