Searchable abstracts of presentations at key conferences in endocrinology

ea0077p111 | Reproductive Endocrinology | SFEBES2021

An investigation of androgen-responsive non-coding RNAs in boys with atypical genitalia without genetic variants in the androgen receptor (AR)

Alimussina Malika , McMillan Martin , Chudleigh Sandra , McNeilly Jane D , Diver Louise A , McGowan Ruth , Tobias Edward S , Faisal Ahmed S

Introduction: Transcriptome analysis of peripheral blood mononuclear cells (PBMC) RNA has identified a set of androgen-responsive non-coding RNAs.Aim: To quantify the androgen-responsive gene expression and investigate its relationship to the testosterone (T) rise following hCG stimulation in boys with no genetic evidence of androgen insensitivity.Methods: Boys with suspected DSD who were evaluated at the Royal Hospital for Childre...

ea0078oc4.7 | Oral Communications 4 | BSPED2021

The use of urinary steroid profiles in monitoring therapy in children with 21-hydroxylase deficiency – results from the CAH-UK cohort study

Bacila Irina , Lawrence Neil , Alvi Sabah , Cheetham Timothy , Crowne Elizabeth , Das Urmi , Dattani Mehul , Davies Justin H , Gevers Evelien , Krone Ruth , Kyriakou Andreas , Patel Leena , Randell Tabitha , Ryan Fiona , S Faisal Ahmed , Keevil Brian , Taylor Norman , Krone Nils

Introduction: Monitoring glucocorticoid (GC) replacement in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) remains challenging. There are disease-specific patterns in the plasma and urinary steroid profiles in 21OHD, a key role being played by the 11-oxygenatedC19 androgens. Aim: To explore the urinary steroid profile in 21OHD in relation to treatment and plasma steroids. Methods: Partic...