Searchable abstracts of presentations at key conferences in endocrinology

ea0031p274 | Pituitary | SFEBES2013

Hypopituitarism presenting with features of stiff person syndrome

Mudaliar R N , Wilson S , Howell S J , Shaunak S , Kaushal K

Introduction: Stiff person syndrome (SPS) is a progressive neurological disorder characterized by fluctuating stiffness and rigidity in both axial and limb muscles. Stiff leg syndrome, an SPS variant mainly affecting limb muscles, is emerging as a distinct identity. The cause of SPS is unknown but an autoimmune pathogenesis is suspected. There are a few reported cases of hypopituitarism presenting with features suggestive of SPS.Case: A 66-year-old woman...

ea0009p166 | Thyroid | BES2005

Triiodothyronine and glucose insulin potassium individually improve cardiovascular performance post coronary artery bypass graft surgery without increasing systemic oxygen consumption

Ranasinghe A , Quinn D , Franklyn J , Graham T , Keogh B , Mascaro J , Rooney S , Wilson I , Pagano D , Bonser R

ObjectivesBoth glucose insulin potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance following cardiac surgery. The effects of combined treatment are unknown.MethodsAfter obtaining local research ethics committee approval, we performed a randomised double-blind placebo-controlled trial on patients undergoing first time elective/urgent isolated CABG. Between January 2000 ...

ea0009oc34 | Oral Communication 5: Thyroid | BES2005

Association between serum TSH and fT4 concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects. The Birmingham Elderly Thyroid Study (BETS)

Gammage M , Parle J , Franklyn J , Wilson S , Roberts L , Holder R , Sheppard M , Hobbs F , Roalfe A , Heath C , Pattison H

We conducted a prospective study of 5784 subjects aged 65 or over, screened and identified in primary care. The cohort comprised 2934 women, 2850 men, mean age 73.5 years (range 63.5-98.6). All had TSH measured in a sensitive assay (normal range 0.4-5.5 mU/l), as well as free T4 (normal range 9-20 pmol/l), and resting 12-lead ECG. Atrial fibrillation (AF) was present in 4.81% of the cohort. The prevalence of AF showed significant variation with serum TSH concentrations, being ...

ea0009p157 | Thyroid | BES2005

The Birmingham Elderly Thyroid Study (BETS): TSH and fT4 values in 5784 community-living subjects aged 60 and over

Parle J , Franklyn J , Wilson S , Roberts L , Holder R , Sheppard M , Hobbs F , Roalfe A , Gammage M , Heath C , Pattison H

Thyroid dysfunction is common, particularly in the elderly, and has an important impact on morbidity and mortality, especially in this age group.Aim: We have investigated associations between thyroid function, presence of atrial fibrillation and cognitive function in a large general practice-based study conducted from December 2002-November 2004. Subjects with a previous history of thyroid disease or currently taking thyroxine or anti-thyroid drugs were ...